Eculizumab treatment for renal failure in a pediatric patient with COVID-19

While there are increasing reports of acute kidney injury among hospitalized adults with COVID-19, there is still limited information on renal complications associated with COVID-19 in children. The cause of kidney involvement in COVID-19 is likely multifactorial, and appears to involve a complex pr...

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Veröffentlicht in:	Journal of nephrology 2020-12, Vol.33 (6), p.1373-1376
Hauptverfasser:	Mahajan, Ruchi, Lipton, Marissa, Broglie, Larisa, Jain, Namrata Gargee, Uy, Natalie Somera
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antibodies, Monoclonal, Humanized - therapeutic use Case Report Comorbidity Complement Inactivating Agents - therapeutic use COVID-19 - epidemiology Female Humans Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - therapy Medicine Medicine & Public Health Nephrology Pandemics Renal Dialysis - methods SARS-CoV-2 Urology
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Zusammenfassung:	While there are increasing reports of acute kidney injury among hospitalized adults with COVID-19, there is still limited information on renal complications associated with COVID-19 in children. The cause of kidney involvement in COVID-19 is likely multifactorial, and appears to involve a complex process, including complement dysregulation and thrombotic microangiopathy. We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with eculizumab.
ISSN:	1121-8428 1724-6059
DOI:	10.1007/s40620-020-00858-2