Recognising the asymptomatic enemy

Recognising the asymptomatic enemy

Using a 36-gene RT-PCR assay, McClain and colleagues could identify differential transcription patterns in infected patients up to 3 days before the development of clinical signs, with an area under the receiver operating characteristic curve of 0·77. [...]they are unable to detect infection of inac...

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Veröffentlicht in:The Lancet infectious diseases 2021-03, Vol.21 (3), p.305-306
Hauptverfasser: Cebey-López, Miriam, Salas, Antonio
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Asymptomatic
Bacterial infections
Biological Evolution
Comment
Epidemics
Gene Expression
Humans
Infections
Infectious diseases
Microorganisms
Mortality
Pandemics
Pathogens
Polymerase chain reaction
Prospective Studies
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Transcription
Viral infections
Viruses
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Beschreibung
Zusammenfassung:Using a 36-gene RT-PCR assay, McClain and colleagues could identify differential transcription patterns in infected patients up to 3 days before the development of clinical signs, with an area under the receiver operating characteristic curve of 0·77. [...]they are unable to detect infection of inaccessible anatomical sites. [...]detecting a particular microorganism does not imply disease causality; another undetected microorganism might be the cause of symptoms.
ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(20)30587-9