HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis

We analyzed 312 drug-resistant genomes of isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mut...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2020-09, Vol.64 (10)
Hauptverfasser:	Loiseau, Chloé, Brites, Daniela, Reinhard, Miriam, Zürcher, Kathrin, Borrell, Sonia, Ballif, Marie, Fenner, Lukas, Cox, Helen, Rutaihwa, Liliana K, Wilkinson, Robert J, Yotebieng, Marcel, Carter, E Jane, Abimiku, Alash'le, Marcy, Olivier, Gotuzzo, Eduardo, Avihingsanon, Anchalee, Zetola, Nicola, Doulla, Basra, Böttger, Erik C, Egger, Matthias, Gagneux, Sebastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Epidemiology and Surveillance
Online-Zugang:	Volltext
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Zusammenfassung:	We analyzed 312 drug-resistant genomes of isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in that are associated with a low fitness in the absence of the drug, suggesting these low-fitness variants can thrive in the context of reduced host immunity.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00782-20