LncRNA AC245100.4 binds HSP90 to promote the proliferation of prostate cancer

To investigate the role and mechanisms of in prostate cancer. The expression and location of were examined using real-time PCR and hybridization. Cell Counting Kit-8, clone formation, flow cytometry and assays were conducted to determine the role of . RNA antisense purification with mass spectrometry and RNA immunoprecipitation were performed to identify proteins that bind to . Western blotting was performed to quantify the expression of protein. expression was upregulated in prostate cancer and mainly located in the cytoplasm. Knockdown of inhibited proliferation of prostate cancer. Mechanistically, bound to HSP90 and altered its chaperone function, increased the stability of IκB kinase and activated the NFκB signaling pathway. promotes the proliferation of prostate cancer via binding of HSP90.