Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
Abstract Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. He...
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| Veröffentlicht in: | Open forum infectious diseases 2020-10, Vol.7 (10), p.ofaa407-ofaa407 |
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| container_issue | 10 |
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| container_title | Open forum infectious diseases |
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| creator | Sierra, Beatriz Pérez, Ana B Aguirre, Eglis Bracho, Claudia Valdés, Odalys Jimenez, Narciso Baldoquin, Waldemar Gonzalez, Guelsys Ortega, Lilia M Montalvo, Maria C Resik, Sonia Alvarez, Delmis Guzmán, Maria G |
| description | Abstract
Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome. |
| doi_str_mv | 10.1093/ofid/ofaa407 |
| format | Article |
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Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofaa407</identifier><identifier>PMID: 33123608</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Brief Reports</subject><ispartof>Open forum infectious diseases, 2020-10, Vol.7 (10), p.ofaa407-ofaa407</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-efe380c66c5f467c3abb21d9ccd87850cda5e3d21709bbb1f4ad6fe8a4253b1f3</citedby><cites>FETCH-LOGICAL-c346t-efe380c66c5f467c3abb21d9ccd87850cda5e3d21709bbb1f4ad6fe8a4253b1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499702/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499702/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33123608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sierra, Beatriz</creatorcontrib><creatorcontrib>Pérez, Ana B</creatorcontrib><creatorcontrib>Aguirre, Eglis</creatorcontrib><creatorcontrib>Bracho, Claudia</creatorcontrib><creatorcontrib>Valdés, Odalys</creatorcontrib><creatorcontrib>Jimenez, Narciso</creatorcontrib><creatorcontrib>Baldoquin, Waldemar</creatorcontrib><creatorcontrib>Gonzalez, Guelsys</creatorcontrib><creatorcontrib>Ortega, Lilia M</creatorcontrib><creatorcontrib>Montalvo, Maria C</creatorcontrib><creatorcontrib>Resik, Sonia</creatorcontrib><creatorcontrib>Alvarez, Delmis</creatorcontrib><creatorcontrib>Guzmán, Maria G</creatorcontrib><title>Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1</title><title>Open forum infectious diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.</description><subject>Brief Reports</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kU1P3DAQhi1EVRBw67nyrRwI-CtfHJBQSulKS3cPsBytiTNh3Sbxrp2sxL8nq90ieunFY2sePTPWS8gXzi45y-WVq201HgCKpQfkWEiRRVkep4cf7kfkLITfjDHOWczS_DM5kpILmbDsmKxvQ3DGQm9dR11N78A3r_QXBLdagn_tXhAaOmnboUP6AP4P-kCfbb-kxWwx-R7xnBaN7awZqdnQG9fiNZ17rKzp7QbpApoBt96imIqrh2Ie8VPyqYYm4Nm-npCnH3ePxc9oOrufFLfTyEiV9BHWKDNmksTEtUpSI6EsBa9yY6oszWJmKohRVoKnLC_LktcKqqTGDJSI5fiUJ-Rm510NZYuVwa730OiVt-34Me3A6n87nV3qF7fRqcrzlIlRcL4XeLceMPS6tcFg00CHbghaqDhRPBMqGdGLHWq8C8Fj_T6GM70NSm-D0vugRvzrx9Xe4b-xjMC3HeCG1f9Vbxwtnig</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Sierra, Beatriz</creator><creator>Pérez, Ana B</creator><creator>Aguirre, Eglis</creator><creator>Bracho, Claudia</creator><creator>Valdés, Odalys</creator><creator>Jimenez, Narciso</creator><creator>Baldoquin, Waldemar</creator><creator>Gonzalez, Guelsys</creator><creator>Ortega, Lilia M</creator><creator>Montalvo, Maria C</creator><creator>Resik, Sonia</creator><creator>Alvarez, Delmis</creator><creator>Guzmán, Maria G</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1</title><author>Sierra, Beatriz ; Pérez, Ana B ; Aguirre, Eglis ; Bracho, Claudia ; Valdés, Odalys ; Jimenez, Narciso ; Baldoquin, Waldemar ; Gonzalez, Guelsys ; Ortega, Lilia M ; Montalvo, Maria C ; Resik, Sonia ; Alvarez, Delmis ; Guzmán, Maria G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-efe380c66c5f467c3abb21d9ccd87850cda5e3d21709bbb1f4ad6fe8a4253b1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Brief Reports</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sierra, Beatriz</creatorcontrib><creatorcontrib>Pérez, Ana B</creatorcontrib><creatorcontrib>Aguirre, Eglis</creatorcontrib><creatorcontrib>Bracho, Claudia</creatorcontrib><creatorcontrib>Valdés, Odalys</creatorcontrib><creatorcontrib>Jimenez, Narciso</creatorcontrib><creatorcontrib>Baldoquin, Waldemar</creatorcontrib><creatorcontrib>Gonzalez, Guelsys</creatorcontrib><creatorcontrib>Ortega, Lilia M</creatorcontrib><creatorcontrib>Montalvo, Maria C</creatorcontrib><creatorcontrib>Resik, Sonia</creatorcontrib><creatorcontrib>Alvarez, Delmis</creatorcontrib><creatorcontrib>Guzmán, Maria G</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open forum infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sierra, Beatriz</au><au>Pérez, Ana B</au><au>Aguirre, Eglis</au><au>Bracho, Claudia</au><au>Valdés, Odalys</au><au>Jimenez, Narciso</au><au>Baldoquin, Waldemar</au><au>Gonzalez, Guelsys</au><au>Ortega, Lilia M</au><au>Montalvo, Maria C</au><au>Resik, Sonia</au><au>Alvarez, Delmis</au><au>Guzmán, Maria G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1</atitle><jtitle>Open forum infectious diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>7</volume><issue>10</issue><spage>ofaa407</spage><epage>ofaa407</epage><pages>ofaa407-ofaa407</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33123608</pmid><doi>10.1093/ofid/ofaa407</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2328-8957 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Brief Reports |
| title | Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1 |
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