Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1

Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1

Abstract Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. He...

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Veröffentlicht in:Open forum infectious diseases 2020-10, Vol.7 (10), p.ofaa407-ofaa407
Hauptverfasser: Sierra, Beatriz, Pérez, Ana B, Aguirre, Eglis, Bracho, Claudia, Valdés, Odalys, Jimenez, Narciso, Baldoquin, Waldemar, Gonzalez, Guelsys, Ortega, Lilia M, Montalvo, Maria C, Resik, Sonia, Alvarez, Delmis, Guzmán, Maria G
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Sprache:eng
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Zusammenfassung:Abstract Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa407