Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients Following Immunomodulatory Therapies

Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients Following Immunomodulatory Therapies

We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of herpes simplex virus 1 reactivation in these patients, undergoing immunomodulatory treatment,...

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Veröffentlicht in:Clinical infectious diseases 2021-07, Vol.73 (1), p.e252-e255
Hauptverfasser: Busani, Stefano, Bedini, Andrea, Biagioni, Emanuela, Serio, Lucia, Tonelli, Roberto, Meschiari, Marianna, Franceschini, Erica, Guaraldi, Giovanni, Cossarizza, Andrea, Clini, Enrico, Maiorana, Antonino, Gennari, William, De Maria, Nicola, Luppi, Mario, Mussini, Cristina, Girardis, Massimo, Andreotti, Alberto, Bondi, Filippo, Chierego, Giovanni, Scotti, Marzia, Ghirardini, Annamaria, Sita, Marco, De Julis, Stefano, Donno, Lara, Dall’Ara, Lorenzo, Di Salvo, Fabrizio, Farinelli, Carlotta, Rinaldi, Laura, Cavazzuti, Ilaria, Ghidoni, Andrea, Buono, Antonio, Ferrari, Elena, Iseppi, Daniela, Maria Ardito, Anna, Coloretti, Irene, Venturelli, Sophie, Munari, Elena, Tosi, Martina, Roat, Erika, Gatto, Ilenia, Sarti, Marco, Bellinazzi, Caterina, Borella, Rebecca, De Biasi, Sara, De Gaetano, Anna, Fidanza, Lucia, Gibellini, Lara, Iannone, Anna, Lo Tartaro, Domenico, Mattioli, Marco, Nasi, Milena, Paolini, Annamaria, Pinti, Marcello, Cozzi-Lepri, Alessandro, Milic, Jovana, Menozzi, Marianna, Cuomo, Gianluca, Orlando, Gabriella, Borghi, Vanni, Santoro, Antonella, Di Gaetano, Margherita, Puzzolante, Cinzia, Carli, Federica, Corradi, Luca, Fantini, Riccardo, Castaniere, Ivana, Tabbì, Luca, Bruzzi, Giulia, Nani, Chiara, Trentacosti, Fabiana, Donatelli, Pierluigi, Rosaria Pellegrino, Maria, Manicardi, Linda, Moretti, Antonio, Vermi, Morgana, Cerbone, Caterina, Pecorari, Monica, Grottola, Antonella, Fregni Serpini, Giulia
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Sprache:eng
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Brief Report
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Zusammenfassung:We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of herpes simplex virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa1246