Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals

Abstract Context Pancreatic steatosis leading to beta-cell failure might be involved in type 2 diabetes (T2D) pathogenesis. Objective We hypothesized that the genetic background modulates the effect of pancreatic fat on beta-cell function and investigated genotype × pancreatic fat interactions on in...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2020-11, Vol.105 (11), p.1-3525
Hauptverfasser:	Wagner, Róbert, Jaghutriz, Benjamin Assad, Gerst, Felicia, Barroso Oquendo, Morgana, Machann, Jürgen, Schick, Fritz, Löffler, Markus W, Nadalin, Silvio, Fend, Falko, Königsrainer, Alfred, Peter, Andreas, Siegel-Axel, Dorothea, Ullrich, Susanne, Häring, Hans-Ulrich, Fritsche, Andreas, Heni, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - diagnostic imaging Aged Beta cells Blood banks Blood Glucose Body Mass Index Clinical s Dextrose Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Diabetes therapy Female Genetic aspects Genetic Predisposition to Disease Genomes Genomics Genotypes Glucose Glucose tolerance Glucose Tolerance Test Glucose tolerance tests Glycosylated hemoglobin Humans Insulin Insulin resistance Insulin Resistance - genetics Insulin secretion Insulin Secretion - genetics Magnetic resonance imaging Male Medical research Medicine, Experimental Middle Aged Pancreas Pancreas - diagnostic imaging Pancreas - metabolism Pancreatic Diseases - diagnostic imaging Pancreatic Diseases - genetics Pancreatic Diseases - metabolism Patients Prediabetic state Secretion Steatosis Surgery Type 2 diabetes
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Zusammenfassung:	Abstract Context Pancreatic steatosis leading to beta-cell failure might be involved in type 2 diabetes (T2D) pathogenesis. Objective We hypothesized that the genetic background modulates the effect of pancreatic fat on beta-cell function and investigated genotype × pancreatic fat interactions on insulin secretion. Design Two observational studies. Setting University hospital. Patients or participants A total of 360 nondiabetic individuals with elevated risk for T2D (Tuebingen Family Study [TUEF]), and 64 patients undergoing pancreatectomy (Pancreas Biobank [PB], HbA1c
ISSN:	0021-972X 1945-7197
DOI:	10.1210/clinem/dgaa435