Discovery of non‐HLA antibodies associated with cardiac allograft rejection and development and validation of a non‐HLA antigen multiplex panel: From bench to bedside

We analyzed humoral immune responses to nonhuman leukocyte antigen (HLA) after cardiac transplantation to identify antibodies associated with allograft rejection. Protein microarray identified 366 non‐HLA antibodies (>1.5 fold, P

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Bibliographische Detailangaben
Veröffentlicht in:	American journal of transplantation 2020-10, Vol.20 (10), p.2768-2780
Hauptverfasser:	Butler, Carrie L., Hickey, Michelle J., Jiang, Ning, Zheng, Ying, Gjertson, David, Zhang, Qiuheng, Rao, Ping, Fishbein, Gregory A., Cadeiras, Martin, Deng, Mario C., Banchs, Hector L., Torre, Guillermo, DeNofrio, David, Eisen, Howard J., Kobashigawa, Jon, Starling, Randall C., Kfoury, Abdallah, Van Bakel, Adrian, Ewald, Gregory, Balazs, Ivan, Baas, Arnold S., Cruz, Daniel, Ardehali, Reza, Biniwale, Reshma, Kwon, Murray, Ardehali, Abbas, Nsair, Ali, Ray, Bryan, Reed, Elaine F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Antibodies Antigens autoantibody autoantigen Autoantigens Biopsy clinical research/practice DNA microarrays Endothelial cells Graft rejection Graft Rejection - diagnosis Graft Rejection - etiology Heart transplantation Heart Transplantation - adverse effects heart transplantation/cardiology Heart transplants histocompatibility Histocompatibility antigen HLA Histocompatibility testing HLA Antigens Immune response (humoral) immunogenetics Membrane proteins microarray/protein array organ transplantation in general Protein arrays Protein folding rejection Synergism translational research/science Transplants & implants
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Beschreibung
Zusammenfassung:	We analyzed humoral immune responses to nonhuman leukocyte antigen (HLA) after cardiac transplantation to identify antibodies associated with allograft rejection. Protein microarray identified 366 non‐HLA antibodies (>1.5 fold, P
ISSN:	1600-6135 1600-6143 1600-6143
DOI:	10.1111/ajt.15863