HIV infection and COVID-19: risk factors for severe disease

HIV infection and COVID-19: risk factors for severe disease

We performed an observational prospective monocentric study in patients living with HIV (PLWH) diagnosed with COVID-19. Fifty-four PLWH developed COVID-19 with 14 severe (25.9%) and five critical cases (9.3%), respectively. By multivariate analysis, age, male sex, ethnic origin from sub-Saharan Afri...

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Veröffentlicht in:AIDS (London) 2020-10, Vol.34 (12), p.1771-1774
Hauptverfasser: Etienne, Nicolas, Karmochkine, Marina, Slama, Laurence, Pavie, Juliette, Batisse, Dominique, Usubillaga, Rafael, Letembet, Valerie-Anne, Brazille, Patricia, Canouï, Etienne, Slama, Dorsaf, Joumaa, Hassan, Canoui-Poitrine, Florence, Segaux, Lauriane, Weiss, Laurence, Viard, Jean-Paul, Salmon, Dominique
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Africa South of the Sahara - ethnology
Anti-Retroviral Agents - therapeutic use
CD4 Lymphocyte Count
Clinical Science: Special Section: Covid-19 among People Living with HIV
Coronavirus Infections - epidemiology
Coronavirus Infections - ethnology
COVID-19
Female
France - epidemiology
HIV Infections - complications
HIV Infections - drug therapy
Humans
Life Sciences
Logistic Models
Male
Metabolic Diseases - complications
Middle Aged
Multivariate Analysis
Pandemics
Pneumonia, Viral - epidemiology
Pneumonia, Viral - ethnology
Prospective Studies
Risk Assessment
Risk Factors
Santé publique et épidémiologie
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Beschreibung
Zusammenfassung:We performed an observational prospective monocentric study in patients living with HIV (PLWH) diagnosed with COVID-19. Fifty-four PLWH developed COVID-19 with 14 severe (25.9%) and five critical cases (9.3%), respectively. By multivariate analysis, age, male sex, ethnic origin from sub-Saharan Africa and metabolic disorder were associated with severe or critical forms of COVID-19. Prior CD4+ T cell counts did not differ between groups. No protective effect of a particular antiretroviral class was observed.
ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000002651