Edge of Scotoma Sensitivity as a Microperimetry Clinical Trial End Point in USH2A Retinopathy
Microperimetry is commonly used to assess retinal function. We perform cross-sectional and longitudinal analysis on microperimetry parameters in retinopathy and explore end points suitable for future clinical trials. Microperimetry was performed using two grids, Grid 1 (18° diameter) and Grid 2 (6°...
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Veröffentlicht in: | Translational vision science & technology 2020-09, Vol.9 (10), p.9-9 |
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Sprache: | eng |
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Zusammenfassung: | Microperimetry is commonly used to assess retinal function. We perform cross-sectional and longitudinal analysis on microperimetry parameters in
retinopathy and explore end points suitable for future clinical trials.
Microperimetry was performed using two grids, Grid 1 (18° diameter) and Grid 2 (6° diameter). In Grid 1, four parameters (number of nonscotomatous loci, mean sensitivity [MS], responding point sensitivity [RPS], and edge of scotoma sensitivity [ESS]) were analyzed. In Grid 2, number of nonscotomatous loci and MS were examined. Interocular symmetry was also examined. Longitudinal analysis was conducted in a subset of eyes.
Microperimetry could be performed in 16 of 21 patients. In Grid 1 (
= 15; average age, 35.6 years), average number of nonscotomatous loci, MS, RPS, and ESS were 46.6 loci, 10.0 dB, 14.7 and 9.6 dB, respectively. In Grid 2 (
= 13; average age, 37.4 years), 12 eyes had measurable sensitivity across the entire grid. Average MS was 23.8 dB. Interocular analysis revealed large 95% confidence intervals for all parameters. Longitudinally, Grid 1 (
= 12, average follow-up 2.6 years) ESS showed the fastest rate of decline (-1.84 dB/y) compared with MS (-0.34 dB/y) and RPS (-0.90 dB/y).
Our data suggest that ESS may be more useful than MS and RPS in test grids that cover a large extent of the macula. We caution the use of contralateral eye as an internal control.
ESS may decrease the duration or sample size of treatment trials in
retinopathy. |
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ISSN: | 2164-2591 2164-2591 |
DOI: | 10.1167/tvst.9.10.9 |