A life‐time of hazardous drinking and harm to health among older adults: findings from the Whitehall II prospective cohort study
Aims To investigate associations of life‐time hazardous and binge drinking with biomarkers of cardiometabolic health, liver function, cardiovascular disease (CVD) and mortality. Design Prospective cohort study with median follow‐up time to CVD incidence of 4.5 years. Setting London, UK: civil servan...
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| Veröffentlicht in: | Addiction (Abingdon, England) England), 2020-10, Vol.115 (10), p.1855-1866 |
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| creator | Ng Fat, Linda Bell, Steven Britton, Annie |
| description | Aims
To investigate associations of life‐time hazardous and binge drinking with biomarkers of cardiometabolic health, liver function, cardiovascular disease (CVD) and mortality.
Design
Prospective cohort study with median follow‐up time to CVD incidence of 4.5 years.
Setting
London, UK: civil servants within the Whitehall II Study.
Participants
A total of 4820 drinkers aged 59–83 years with biological measurements during the 2011–12 survey.
Measurements
Hazardous drinking was defined as having an AUDIT‐C score ≥ 5 calculated at each decade of life, forming the following groups: never hazardous drinker, former early (stopping before age 50), former later (stopping after age 50), current hazardous drinker and consistent hazardous drinker (hazardous drinker at each decade of life).
Findings
More than half the sample had been hazardous drinkers at some point during their life‐time, comprising former early ( |
| doi_str_mv | 10.1111/add.15013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7487058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2441383469</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4433-5d1af1de2f67f18b093517f81bbb5e8822154b78241f913793744105cedaada33</originalsourceid><addsrcrecordid>eNp1kc9qFTEUxoMo9lpd-AIScKOLafN3knEhXNqqFwpuFJchM0k6qZnJNclUrivxCfqMPonRW4sKns2Bc358fOd8ADzG6AjXOtbGHGGOML0DVpi2qEGM0btghbqWNwQzdAAe5HyJEBKyY_fBASWEUkzoCnxbw-Cd_f71uvjJwujgqL_oZOKSoUl-_ujnC6hnU8dpgiXC0epQRqinWBcxGJugNkso-QV0fjYVz9ClWNnRwg-jL3bUIcDNBm5TzFs7FH9l4RDHmArMZTG7h-Ce0yHbRzf9ELx_dfbu5E1z_vb15mR93gz1Gtpwg7XDxhLXCodljzrKsXAS933PrZSEYM56IQnDrsNUdFQwhhEfrNHaaEoPwcu97nbpJ2sGO5ekg9omP-m0U1F79fdm9qO6iFdKMCkQl1Xg2Y1Aip8Wm4uafB5sCHq29V-KUMlJ23VCVPTpP-hlXNJcz1OkuqKSsrar1PM9NdTX5GTdrRmM1M9kVU1W_Uq2sk_-dH9L_o6yAsd74LMPdvd_JbU-Pd1L_gDwfa8i</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2441383469</pqid></control><display><type>article</type><title>A life‐time of hazardous drinking and harm to health among older adults: findings from the Whitehall II prospective cohort study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ng Fat, Linda ; Bell, Steven ; Britton, Annie</creator><creatorcontrib>Ng Fat, Linda ; Bell, Steven ; Britton, Annie</creatorcontrib><description>Aims
To investigate associations of life‐time hazardous and binge drinking with biomarkers of cardiometabolic health, liver function, cardiovascular disease (CVD) and mortality.
Design
Prospective cohort study with median follow‐up time to CVD incidence of 4.5 years.
Setting
London, UK: civil servants within the Whitehall II Study.
Participants
A total of 4820 drinkers aged 59–83 years with biological measurements during the 2011–12 survey.
Measurements
Hazardous drinking was defined as having an AUDIT‐C score ≥ 5 calculated at each decade of life, forming the following groups: never hazardous drinker, former early (stopping before age 50), former later (stopping after age 50), current hazardous drinker and consistent hazardous drinker (hazardous drinker at each decade of life).
Findings
More than half the sample had been hazardous drinkers at some point during their life‐time, comprising former early (< age 50) (19%), former later (≥ age 50) (11%), current (21%) and consistent hazardous drinker (AUDIT‐C ≥ 5 across life (5%). After adjusting for covariates, waist circumference was larger with more persistent hazardous drinking (e.g. compared with never hazardous drinkers, former early had increased waist circumference by 1.17 cm [95% confidence interval (CI) = 0.25‐2.08]; former later by 1.88 cm (CI = 0.77–2.98); current by 2.44 cm (CI = 1.50–3.34) and consistent hazardous drinker by 3.85 cm (CI = 2.23–5.47). Current hazardous drinkers had higher systolic blood pressure (2.44 mmHg, CI = 1.19–3.68) and fatty liver index scores (4.05 mmHg, CI = 2.92–5.18) than never hazardous drinkers. Current hazardous drinkers [hazard ratio (HR) = 2.75, CI = 1.44–5.22) had an elevated risk of stroke, and former later hazardous drinkers had an elevated risk of non‐CVD mortality (HR = 1.93, CI = 1.19–3.14) than never hazardous drinkers. Life‐time binge drinking was associated with larger waist circumferences and poorer liver function compared with never binge drinkers.
Conclusion
Hazardous drinking may increase cardiometabolic risk factors; this is made worse by persistent hazardous drinking throughout life, particularly in relation to weight gain, suggesting benefits of early intervention.</description><identifier>ISSN: 0965-2140</identifier><identifier>ISSN: 1360-0443</identifier><identifier>EISSN: 1360-0443</identifier><identifier>DOI: 10.1111/add.15013</identifier><identifier>PMID: 32233123</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Age ; Aged ; Aged, 80 and over ; Ageing ; Alcohol Drinking - epidemiology ; Alcohol use ; Alcohol-Related Disorders - epidemiology ; binge drinking ; Biological markers ; Biomarkers ; Blood pressure ; cardiometabolic ; Cardiometabolic Risk Factors ; cardiovascular ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cause of Death ; Cohort analysis ; Cohort Studies ; Drinking ; Drinking behavior ; Early intervention ; Fatty liver ; Female ; hazardous consumption ; Health Status ; Humans ; Life expectancy ; Liver ; Liver diseases ; liver function ; London - epidemiology ; Male ; Middle Aged ; Mortality ; Older people ; Proportional Hazards Models ; Prospective Studies ; Research Report ; Research Reports ; Risk factors ; Surveys and Questionnaires ; Weight gain</subject><ispartof>Addiction (Abingdon, England), 2020-10, Vol.115 (10), p.1855-1866</ispartof><rights>2020 The Authors. published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction</rights><rights>2020 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.</rights><rights>2020. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4433-5d1af1de2f67f18b093517f81bbb5e8822154b78241f913793744105cedaada33</citedby><cites>FETCH-LOGICAL-c4433-5d1af1de2f67f18b093517f81bbb5e8822154b78241f913793744105cedaada33</cites><orcidid>0000-0002-6412-5430 ; 0000-0001-6774-3149 ; 0000-0002-7282-9526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fadd.15013$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fadd.15013$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32233123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng Fat, Linda</creatorcontrib><creatorcontrib>Bell, Steven</creatorcontrib><creatorcontrib>Britton, Annie</creatorcontrib><title>A life‐time of hazardous drinking and harm to health among older adults: findings from the Whitehall II prospective cohort study</title><title>Addiction (Abingdon, England)</title><addtitle>Addiction</addtitle><description>Aims
To investigate associations of life‐time hazardous and binge drinking with biomarkers of cardiometabolic health, liver function, cardiovascular disease (CVD) and mortality.
Design
Prospective cohort study with median follow‐up time to CVD incidence of 4.5 years.
Setting
London, UK: civil servants within the Whitehall II Study.
Participants
A total of 4820 drinkers aged 59–83 years with biological measurements during the 2011–12 survey.
Measurements
Hazardous drinking was defined as having an AUDIT‐C score ≥ 5 calculated at each decade of life, forming the following groups: never hazardous drinker, former early (stopping before age 50), former later (stopping after age 50), current hazardous drinker and consistent hazardous drinker (hazardous drinker at each decade of life).
Findings
More than half the sample had been hazardous drinkers at some point during their life‐time, comprising former early (< age 50) (19%), former later (≥ age 50) (11%), current (21%) and consistent hazardous drinker (AUDIT‐C ≥ 5 across life (5%). After adjusting for covariates, waist circumference was larger with more persistent hazardous drinking (e.g. compared with never hazardous drinkers, former early had increased waist circumference by 1.17 cm [95% confidence interval (CI) = 0.25‐2.08]; former later by 1.88 cm (CI = 0.77–2.98); current by 2.44 cm (CI = 1.50–3.34) and consistent hazardous drinker by 3.85 cm (CI = 2.23–5.47). Current hazardous drinkers had higher systolic blood pressure (2.44 mmHg, CI = 1.19–3.68) and fatty liver index scores (4.05 mmHg, CI = 2.92–5.18) than never hazardous drinkers. Current hazardous drinkers [hazard ratio (HR) = 2.75, CI = 1.44–5.22) had an elevated risk of stroke, and former later hazardous drinkers had an elevated risk of non‐CVD mortality (HR = 1.93, CI = 1.19–3.14) than never hazardous drinkers. Life‐time binge drinking was associated with larger waist circumferences and poorer liver function compared with never binge drinkers.
Conclusion
Hazardous drinking may increase cardiometabolic risk factors; this is made worse by persistent hazardous drinking throughout life, particularly in relation to weight gain, suggesting benefits of early intervention.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ageing</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol use</subject><subject>Alcohol-Related Disorders - epidemiology</subject><subject>binge drinking</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>cardiometabolic</subject><subject>Cardiometabolic Risk Factors</subject><subject>cardiovascular</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cause of Death</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Drinking</subject><subject>Drinking behavior</subject><subject>Early intervention</subject><subject>Fatty liver</subject><subject>Female</subject><subject>hazardous consumption</subject><subject>Health Status</subject><subject>Humans</subject><subject>Life expectancy</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>liver function</subject><subject>London - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Older people</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Research Report</subject><subject>Research Reports</subject><subject>Risk factors</subject><subject>Surveys and Questionnaires</subject><subject>Weight gain</subject><issn>0965-2140</issn><issn>1360-0443</issn><issn>1360-0443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kc9qFTEUxoMo9lpd-AIScKOLafN3knEhXNqqFwpuFJchM0k6qZnJNclUrivxCfqMPonRW4sKns2Bc358fOd8ADzG6AjXOtbGHGGOML0DVpi2qEGM0btghbqWNwQzdAAe5HyJEBKyY_fBASWEUkzoCnxbw-Cd_f71uvjJwujgqL_oZOKSoUl-_ujnC6hnU8dpgiXC0epQRqinWBcxGJugNkso-QV0fjYVz9ClWNnRwg-jL3bUIcDNBm5TzFs7FH9l4RDHmArMZTG7h-Ce0yHbRzf9ELx_dfbu5E1z_vb15mR93gz1Gtpwg7XDxhLXCodljzrKsXAS933PrZSEYM56IQnDrsNUdFQwhhEfrNHaaEoPwcu97nbpJ2sGO5ekg9omP-m0U1F79fdm9qO6iFdKMCkQl1Xg2Y1Aip8Wm4uafB5sCHq29V-KUMlJ23VCVPTpP-hlXNJcz1OkuqKSsrar1PM9NdTX5GTdrRmM1M9kVU1W_Uq2sk_-dH9L_o6yAsd74LMPdvd_JbU-Pd1L_gDwfa8i</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Ng Fat, Linda</creator><creator>Bell, Steven</creator><creator>Britton, Annie</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6412-5430</orcidid><orcidid>https://orcid.org/0000-0001-6774-3149</orcidid><orcidid>https://orcid.org/0000-0002-7282-9526</orcidid></search><sort><creationdate>202010</creationdate><title>A life‐time of hazardous drinking and harm to health among older adults: findings from the Whitehall II prospective cohort study</title><author>Ng Fat, Linda ; Bell, Steven ; Britton, Annie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4433-5d1af1de2f67f18b093517f81bbb5e8822154b78241f913793744105cedaada33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ageing</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol use</topic><topic>Alcohol-Related Disorders - epidemiology</topic><topic>binge drinking</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Blood pressure</topic><topic>cardiometabolic</topic><topic>Cardiometabolic Risk Factors</topic><topic>cardiovascular</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - mortality</topic><topic>Cause of Death</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Drinking</topic><topic>Drinking behavior</topic><topic>Early intervention</topic><topic>Fatty liver</topic><topic>Female</topic><topic>hazardous consumption</topic><topic>Health Status</topic><topic>Humans</topic><topic>Life expectancy</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>liver function</topic><topic>London - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Older people</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Research Report</topic><topic>Research Reports</topic><topic>Risk factors</topic><topic>Surveys and Questionnaires</topic><topic>Weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng Fat, Linda</creatorcontrib><creatorcontrib>Bell, Steven</creatorcontrib><creatorcontrib>Britton, Annie</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Addiction (Abingdon, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng Fat, Linda</au><au>Bell, Steven</au><au>Britton, Annie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A life‐time of hazardous drinking and harm to health among older adults: findings from the Whitehall II prospective cohort study</atitle><jtitle>Addiction (Abingdon, England)</jtitle><addtitle>Addiction</addtitle><date>2020-10</date><risdate>2020</risdate><volume>115</volume><issue>10</issue><spage>1855</spage><epage>1866</epage><pages>1855-1866</pages><issn>0965-2140</issn><issn>1360-0443</issn><eissn>1360-0443</eissn><abstract>Aims
To investigate associations of life‐time hazardous and binge drinking with biomarkers of cardiometabolic health, liver function, cardiovascular disease (CVD) and mortality.
Design
Prospective cohort study with median follow‐up time to CVD incidence of 4.5 years.
Setting
London, UK: civil servants within the Whitehall II Study.
Participants
A total of 4820 drinkers aged 59–83 years with biological measurements during the 2011–12 survey.
Measurements
Hazardous drinking was defined as having an AUDIT‐C score ≥ 5 calculated at each decade of life, forming the following groups: never hazardous drinker, former early (stopping before age 50), former later (stopping after age 50), current hazardous drinker and consistent hazardous drinker (hazardous drinker at each decade of life).
Findings
More than half the sample had been hazardous drinkers at some point during their life‐time, comprising former early (< age 50) (19%), former later (≥ age 50) (11%), current (21%) and consistent hazardous drinker (AUDIT‐C ≥ 5 across life (5%). After adjusting for covariates, waist circumference was larger with more persistent hazardous drinking (e.g. compared with never hazardous drinkers, former early had increased waist circumference by 1.17 cm [95% confidence interval (CI) = 0.25‐2.08]; former later by 1.88 cm (CI = 0.77–2.98); current by 2.44 cm (CI = 1.50–3.34) and consistent hazardous drinker by 3.85 cm (CI = 2.23–5.47). Current hazardous drinkers had higher systolic blood pressure (2.44 mmHg, CI = 1.19–3.68) and fatty liver index scores (4.05 mmHg, CI = 2.92–5.18) than never hazardous drinkers. Current hazardous drinkers [hazard ratio (HR) = 2.75, CI = 1.44–5.22) had an elevated risk of stroke, and former later hazardous drinkers had an elevated risk of non‐CVD mortality (HR = 1.93, CI = 1.19–3.14) than never hazardous drinkers. Life‐time binge drinking was associated with larger waist circumferences and poorer liver function compared with never binge drinkers.
Conclusion
Hazardous drinking may increase cardiometabolic risk factors; this is made worse by persistent hazardous drinking throughout life, particularly in relation to weight gain, suggesting benefits of early intervention.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>32233123</pmid><doi>10.1111/add.15013</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6412-5430</orcidid><orcidid>https://orcid.org/0000-0001-6774-3149</orcidid><orcidid>https://orcid.org/0000-0002-7282-9526</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Age Aged Aged, 80 and over Ageing Alcohol Drinking - epidemiology Alcohol use Alcohol-Related Disorders - epidemiology binge drinking Biological markers Biomarkers Blood pressure cardiometabolic Cardiometabolic Risk Factors cardiovascular Cardiovascular diseases Cardiovascular Diseases - mortality Cause of Death Cohort analysis Cohort Studies Drinking Drinking behavior Early intervention Fatty liver Female hazardous consumption Health Status Humans Life expectancy Liver Liver diseases liver function London - epidemiology Male Middle Aged Mortality Older people Proportional Hazards Models Prospective Studies Research Report Research Reports Risk factors Surveys and Questionnaires Weight gain |
| title | A life‐time of hazardous drinking and harm to health among older adults: findings from the Whitehall II prospective cohort study |
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