Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis

Multiple myeloma (MM) cell lines are routinely used to model the disease. However, a long-standing question is how well these cell lines truly represent tumor cells in patients. Here, we employ a recently described method of transcriptional correlation profiling to compare similarity of 66 MM cell l...

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Veröffentlicht in:Leukemia 2020-10, Vol.34 (10), p.2754-2765
Hauptverfasser: Sarin, Vishesh, Yu, Katharine, Ferguson, Ian D., Gugliemini, Olivia, Nix, Matthew A., Hann, Byron, Sirota, Marina, Wiita, Arun P.
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Sprache:eng
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Zusammenfassung:Multiple myeloma (MM) cell lines are routinely used to model the disease. However, a long-standing question is how well these cell lines truly represent tumor cells in patients. Here, we employ a recently described method of transcriptional correlation profiling to compare similarity of 66 MM cell lines to 779 newly diagnosed MM patient tumors. We found that individual MM lines differ significantly with respect to patient tumor representation, with median R ranging from 0.35 to 0.54. ANBL-6 was the “best” line, markedly exceeding all others ( p  
ISSN:0887-6924
1476-5551
DOI:10.1038/s41375-020-0785-1