Regional variations in Helicobacter pylori infection, gastric atrophy and gastric cancer risk: The ENIGMA study in Chile

Background Regional variations in gastric cancer incidence are not explained by prevalence ofHelicobacter pylori, the main cause of the disease, with several areas presenting highH.pyloriprevalence but low gastric cancer incidence. The IARC worldwideH.pyloriprevalence surveys (ENIGMA) aim at systema...

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Veröffentlicht in:	PloS one 2020-09, Vol.15 (9), p.e0237515, Article 0237515
Hauptverfasser:	Herrero, Rolando, Heise, Katy, Acevedo, Johanna, Cook, Paz, Gonzalez, Claudia, Gahona, Jocelyne, Cortes, Raimundo, Collado, Luis, Beltran, Maria Enriqueta, Cikutovic, Marcos, Gonzalez, Paula, Murillo, Raul, Leja, Marcis, Megraud, Francis, Hernandez, Maria de la Luz, Barbier, Sylvaine, Park, Jin Young, Ferreccio, Catterina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Aged Antibodies Atrophy Atrophy - etiology Atrophy - microbiology Atrophy - pathology Biology and Life Sciences Biomarkers Cancer Carcinogenesis Carcinogens Child Child, Preschool Chile - epidemiology Chronic illnesses Cofactors Complications and side effects Consumption Diet Distribution Epidemiology Ethics Female Gastric cancer Gastritis Health care Health promotion Health risks Health sciences Helicobacter infections Helicobacter Infections - complications Helicobacter Infections - epidemiology Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori Helicobacter pylori - isolation & purification Hospitals Human health and pathology Humans Immunoglobulin G Infant Infections Informed consent Laboratories Life Sciences Male Medicine and Health Sciences Middle Aged Mortality Multidisciplinary Sciences People and Places Population Prevalence Preventive medicine Public health Research and Analysis Methods Risk analysis Risk Factors Science & Technology Science & Technology - Other Topics Serology Sex Sexes Stomach - microbiology Stomach - pathology Stomach cancer Stomach Neoplasms - etiology Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Trends Variation Virulence Virulence factors World population Young Adult
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Zusammenfassung:	Background Regional variations in gastric cancer incidence are not explained by prevalence ofHelicobacter pylori, the main cause of the disease, with several areas presenting highH.pyloriprevalence but low gastric cancer incidence. The IARC worldwideH.pyloriprevalence surveys (ENIGMA) aim at systematically describing age and sex-specific prevalence ofH.pyloriinfection around the world and generating hypotheses to explain regional variations in gastric cancer risk. Methods We selected age- and sex-stratified population samples in two areas with different gastric cancer incidence and mortality in Chile: Antofagasta (lower rate) and Valdivia (higher rate). Participants were 1-69 years old and provided interviews and blood for anti-H.pyloriantibodies (IgG, VacA, CagA, others) and atrophy biomarkers (pepsinogens). Results H.pyloriseroprevalence (Age-standardized to world population) and antibodies against CagA and VacA were similar in both sites.H.pyloriseroprevalence was 20% among children
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0237515