HIV-1 Subtype Distribution and Diversity Over 18 Years in Rakai, Uganda

The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2...

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Veröffentlicht in:	AIDS research and human retroviruses 2020-06, Vol.36 (6), p.522-526
Hauptverfasser:	Lamers, Susanna L, Rose, Rebecca, Cross, Sissy, Rodriguez, Christopher W, Redd, Andrew D, Quinn, Thomas C, Serwadda, David, Kagaayi, Joseph, Kigozi, Godfrey, Galiwango, Ronald, Gray, Ronald H, Grabowski, M Kate, Laeyendecker, Oliver
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antiretroviral agents Antiretroviral therapy Genetic diversity Genetic Variation Glycoprotein gp41 HIV HIV Core Protein p24 - genetics HIV Envelope Protein gp41 - genetics HIV Infections - epidemiology HIV Infections - virology HIV-1 - classification Human immunodeficiency virus Humans Middle Aged Polls & surveys Prospective Studies Sequence Notes Uganda - epidemiology Young Adult
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Zusammenfassung:	The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era (
ISSN:	0889-2229 1931-8405
DOI:	10.1089/AID.2020.0062