Cine-Substitutions at Five-Membered Hetarenes Enabled by Sulfonium Salts

Cine-Substitutions at Five-Membered Hetarenes Enabled by Sulfonium Salts

We report a nucleophilic substitution reaction of five-membered hetarylsulfonium salts that results in a change of the substitution pattern on the arene. The products of these cine-substitutions are hard to access synthetically otherwise. The sulfonium salts that serve as starting materials are gene...

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Veröffentlicht in:Organic letters 2020-07, Vol.22 (14), p.5671-5674
Hauptverfasser: Berger, Florian, Alvarez, Eva Maria, Frank, Nils, Bohdan, Kostiantyn, Kondratiuk, Mykhailo, Torkowski, Luca, Engl, Pascal S, Barletta, Joana, Ritter, Tobias
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Sprache:eng
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Zusammenfassung:We report a nucleophilic substitution reaction of five-membered hetarylsulfonium salts that results in a change of the substitution pattern on the arene. The products of these cine-substitutions are hard to access synthetically otherwise. The sulfonium salts that serve as starting materials are generated by a highly site-selective C–H functionalization reaction.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c02067