Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial
Treatment with 20 mg of zinc daily for 10 to 14 days in children with acute diarrhea has been shown to improve diarrhea but increase vomiting. In this randomized trial involving children in Tanzania and India, 5 mg and 10 mg of daily zinc were noninferior to 20 mg of zinc for diarrhea and resulted i...
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| Veröffentlicht in: | The New England journal of medicine 2020-09, Vol.383 (13), p.1231-1241 |
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| container_title | The New England journal of medicine |
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| creator | Dhingra, Usha Kisenge, Rodrick Sudfeld, Christopher R Dhingra, Pratibha Somji, Sarah Dutta, Arup Bakari, Mohamed Deb, Saikat Devi, Prabhabati Liu, Enju Chauhan, Aishwarya Kumar, Jitendra Semwal, Om P Aboud, Said Bahl, Rajiv Ashorn, Per Simon, Jonathon Duggan, Christopher P Sazawal, Sunil Manji, Karim |
| description | Treatment with 20 mg of zinc daily for 10 to 14 days in children with acute diarrhea has been shown to improve diarrhea but increase vomiting. In this randomized trial involving children in Tanzania and India, 5 mg and 10 mg of daily zinc were noninferior to 20 mg of zinc for diarrhea and resulted in less vomiting. |
| doi_str_mv | 10.1056/NEJMoa1915905 |
| format | Article |
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All rights reserved.</rights><rights>Copyright © 2020 Massachusetts Medical Society.</rights><rights>Copyright © 2020 Massachusetts Medical Society. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-8cd2f5097d3e8f565e6dc9c24b70e402294f740dc6dc73303e667e0f2c4dac8a3</citedby><cites>FETCH-LOGICAL-c445t-8cd2f5097d3e8f565e6dc9c24b70e402294f740dc6dc73303e667e0f2c4dac8a3</cites><orcidid>0000-0001-6740-549X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1915905$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2445543404?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32966722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhingra, Usha</creatorcontrib><creatorcontrib>Kisenge, Rodrick</creatorcontrib><creatorcontrib>Sudfeld, Christopher R</creatorcontrib><creatorcontrib>Dhingra, Pratibha</creatorcontrib><creatorcontrib>Somji, Sarah</creatorcontrib><creatorcontrib>Dutta, Arup</creatorcontrib><creatorcontrib>Bakari, Mohamed</creatorcontrib><creatorcontrib>Deb, Saikat</creatorcontrib><creatorcontrib>Devi, Prabhabati</creatorcontrib><creatorcontrib>Liu, Enju</creatorcontrib><creatorcontrib>Chauhan, Aishwarya</creatorcontrib><creatorcontrib>Kumar, Jitendra</creatorcontrib><creatorcontrib>Semwal, Om P</creatorcontrib><creatorcontrib>Aboud, Said</creatorcontrib><creatorcontrib>Bahl, Rajiv</creatorcontrib><creatorcontrib>Ashorn, Per</creatorcontrib><creatorcontrib>Simon, Jonathon</creatorcontrib><creatorcontrib>Duggan, Christopher P</creatorcontrib><creatorcontrib>Sazawal, Sunil</creatorcontrib><creatorcontrib>Manji, Karim</creatorcontrib><title>Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Treatment with 20 mg of zinc daily for 10 to 14 days in children with acute diarrhea has been shown to improve diarrhea but increase vomiting. 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| source | MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland |
| subjects | Ambulatory care Antidiarrheals - administration & dosage Antidiarrheals - adverse effects Antidiarrheals - blood Caregivers Child, Preschool Childhood Children Clinical trials Diarrhea Diarrhea - drug therapy Diarrhea, Infantile - drug therapy Dosage Dose-Response Relationship, Drug Double-Blind Method Enrollments Ethics Female Health facilities Humans Illnesses Infant Male Medication Adherence Trace elements Vomiting Vomiting - chemically induced Vomiting - epidemiology Zinc Zinc - administration & dosage Zinc - adverse effects Zinc - blood Zinc sulfate |
| title | Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial |
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