Lower-Dose Zinc for Childhood Diarrhea — A Randomized, Multicenter Trial

Treatment with 20 mg of zinc daily for 10 to 14 days in children with acute diarrhea has been shown to improve diarrhea but increase vomiting. In this randomized trial involving children in Tanzania and India, 5 mg and 10 mg of daily zinc were noninferior to 20 mg of zinc for diarrhea and resulted i...

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Veröffentlicht in:	The New England journal of medicine 2020-09, Vol.383 (13), p.1231-1241
Hauptverfasser:	Dhingra, Usha, Kisenge, Rodrick, Sudfeld, Christopher R, Dhingra, Pratibha, Somji, Sarah, Dutta, Arup, Bakari, Mohamed, Deb, Saikat, Devi, Prabhabati, Liu, Enju, Chauhan, Aishwarya, Kumar, Jitendra, Semwal, Om P, Aboud, Said, Bahl, Rajiv, Ashorn, Per, Simon, Jonathon, Duggan, Christopher P, Sazawal, Sunil, Manji, Karim
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambulatory care Antidiarrheals - administration & dosage Antidiarrheals - adverse effects Antidiarrheals - blood Caregivers Child, Preschool Childhood Children Clinical trials Diarrhea Diarrhea - drug therapy Diarrhea, Infantile - drug therapy Dosage Dose-Response Relationship, Drug Double-Blind Method Enrollments Ethics Female Health facilities Humans Illnesses Infant Male Medication Adherence Trace elements Vomiting Vomiting - chemically induced Vomiting - epidemiology Zinc Zinc - administration & dosage Zinc - adverse effects Zinc - blood Zinc sulfate
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Zusammenfassung:	Treatment with 20 mg of zinc daily for 10 to 14 days in children with acute diarrhea has been shown to improve diarrhea but increase vomiting. In this randomized trial involving children in Tanzania and India, 5 mg and 10 mg of daily zinc were noninferior to 20 mg of zinc for diarrhea and resulted in less vomiting.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1915905