A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals

Abstract Background and Aims Genome-wide association studies [GWASs] of European populations have identified numerous susceptibility loci for Crohn’s disease [CD]. Susceptibility genes differ by ethnicity, however, so GWASs specific for Asian populations are required. This study aimed to clarify the...

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Veröffentlicht in:Journal of Crohn's and colitis 2019-04, Vol.13 (5), p.648-658
Hauptverfasser: Kakuta, Yoichi, Kawai, Yosuke, Naito, Takeo, Hirano, Atsushi, Umeno, Junji, Fuyuno, Yuta, Liu, Zhenqiu, Li, Dalin, Nakano, Takeru, Izumiyama, Yasuhiro, Ichikawa, Ryo, Okamoto, Daisuke, Nagai, Hiroshi, Matsumoto, Shin, Yamamoto, Katsutoshi, Yokoyama, Naonobu, Chiba, Hirofumi, Shimoyama, Yusuke, Onodera, Motoyuki, Moroi, Rintaro, Kuroha, Masatake, Kanazawa, Yoshitake, Kimura, Tomoya, Shiga, Hisashi, Endo, Katsuya, Negoro, Kenichi, Yasuda, Jun, Esaki, Motohiro, Tokunaga, Katsushi, Nakamura, Minoru, Matsumoto, Takayuki, McGovern, Dermot P B, Nagasaki, Masao, Kinouchi, Yoshitaka, Shimosegawa, Tooru, Masamune, Atsushi
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container_title Journal of Crohn's and colitis
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creator Kakuta, Yoichi
Kawai, Yosuke
Naito, Takeo
Hirano, Atsushi
Umeno, Junji
Fuyuno, Yuta
Liu, Zhenqiu
Li, Dalin
Nakano, Takeru
Izumiyama, Yasuhiro
Ichikawa, Ryo
Okamoto, Daisuke
Nagai, Hiroshi
Matsumoto, Shin
Yamamoto, Katsutoshi
Yokoyama, Naonobu
Chiba, Hirofumi
Shimoyama, Yusuke
Onodera, Motoyuki
Moroi, Rintaro
Kuroha, Masatake
Kanazawa, Yoshitake
Kimura, Tomoya
Shiga, Hisashi
Endo, Katsuya
Negoro, Kenichi
Yasuda, Jun
Esaki, Motohiro
Tokunaga, Katsushi
Nakamura, Minoru
Matsumoto, Takayuki
McGovern, Dermot P B
Nagasaki, Masao
Kinouchi, Yoshitaka
Shimosegawa, Tooru
Masamune, Atsushi
description Abstract Background and Aims Genome-wide association studies [GWASs] of European populations have identified numerous susceptibility loci for Crohn’s disease [CD]. Susceptibility genes differ by ethnicity, however, so GWASs specific for Asian populations are required. This study aimed to clarify the Japanese-specific genetic background for CD by a GWAS using the Japonica array [JPA] and subsequent imputation with the 1KJPN reference panel. Methods Two independent Japanese case/control sets (Tohoku region [379 CD patients, 1621 controls] and Kyushu region [334 CD patients, 462 controls]) were included. GWASs were performed separately for each population, followed by a meta-analysis. Two additional replication sets [254 + 516 CD patients and 287 + 565 controls] were analysed for top hit single nucleotide polymorphisms [SNPs] from novel genomic regions. Results Genotype data of 4 335 144 SNPs from 713 Japanese CD patients and 2083 controls were analysed. SNPs located in TNFSF15 (rs78898421, Pmeta = 2.59 × 10−26, odds ratio [OR] = 2.10), HLA-DQB1 [rs184950714, pmeta = 3.56 × 10−19, OR = 2.05], ZNF365, and 4p14 loci were significantly associated with CD in Japanese individuals. Replication analyses were performed for four novel candidate loci [p
doi_str_mv 10.1093/ecco-jcc/jjy197
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Susceptibility genes differ by ethnicity, however, so GWASs specific for Asian populations are required. This study aimed to clarify the Japanese-specific genetic background for CD by a GWAS using the Japonica array [JPA] and subsequent imputation with the 1KJPN reference panel. Methods Two independent Japanese case/control sets (Tohoku region [379 CD patients, 1621 controls] and Kyushu region [334 CD patients, 462 controls]) were included. GWASs were performed separately for each population, followed by a meta-analysis. Two additional replication sets [254 + 516 CD patients and 287 + 565 controls] were analysed for top hit single nucleotide polymorphisms [SNPs] from novel genomic regions. Results Genotype data of 4 335 144 SNPs from 713 Japanese CD patients and 2083 controls were analysed. SNPs located in TNFSF15 (rs78898421, Pmeta = 2.59 × 10−26, odds ratio [OR] = 2.10), HLA-DQB1 [rs184950714, pmeta = 3.56 × 10−19, OR = 2.05], ZNF365, and 4p14 loci were significantly associated with CD in Japanese individuals. Replication analyses were performed for four novel candidate loci [p &lt;1 × 10−6], and rs488200 located upstream of RAP1A was significantly associated with CD [pcombined = 4.36 × 10−8, OR = 1.31]. Transcriptome analysis of CD4+ effector memory T cells from lamina propria mononuclear cells of CD patients revealed a significant association of rs488200 with RAP1A expression. Conclusions RAP1A is a novel susceptibility locus for CD in the Japanese population.</description><identifier>ISSN: 1873-9946</identifier><identifier>EISSN: 1876-4479</identifier><identifier>DOI: 10.1093/ecco-jcc/jjy197</identifier><identifier>PMID: 30500874</identifier><language>eng</language><publisher>UK: Oxford University Press</publisher><subject>Adult ; Case-Control Studies ; Crohn Disease - epidemiology ; Crohn Disease - genetics ; Female ; Gene Expression Profiling ; Genetic Predisposition to Disease - genetics ; Genome-Wide Association Study ; Humans ; Japan - epidemiology ; Male ; Original ; Polymorphism, Single Nucleotide - genetics ; rap1 GTP-Binding Proteins - genetics ; rap1 GTP-Binding Proteins - physiology ; Young Adult</subject><ispartof>Journal of Crohn's and colitis, 2019-04, Vol.13 (5), p.648-658</ispartof><rights>Copyright © 2018 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. 
For permissions, please email: journals.permissions@oup.com 2018</rights><rights>Copyright © 2018 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. 
For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-3140248bf5f49e7315b1397f9edcb1393abf77ac09075fc8108c47dd2e0c553</citedby><cites>FETCH-LOGICAL-c494t-3140248bf5f49e7315b1397f9edcb1393abf77ac09075fc8108c47dd2e0c553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30500874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kakuta, Yoichi</creatorcontrib><creatorcontrib>Kawai, Yosuke</creatorcontrib><creatorcontrib>Naito, Takeo</creatorcontrib><creatorcontrib>Hirano, Atsushi</creatorcontrib><creatorcontrib>Umeno, Junji</creatorcontrib><creatorcontrib>Fuyuno, Yuta</creatorcontrib><creatorcontrib>Liu, Zhenqiu</creatorcontrib><creatorcontrib>Li, Dalin</creatorcontrib><creatorcontrib>Nakano, Takeru</creatorcontrib><creatorcontrib>Izumiyama, Yasuhiro</creatorcontrib><creatorcontrib>Ichikawa, Ryo</creatorcontrib><creatorcontrib>Okamoto, Daisuke</creatorcontrib><creatorcontrib>Nagai, Hiroshi</creatorcontrib><creatorcontrib>Matsumoto, Shin</creatorcontrib><creatorcontrib>Yamamoto, Katsutoshi</creatorcontrib><creatorcontrib>Yokoyama, Naonobu</creatorcontrib><creatorcontrib>Chiba, Hirofumi</creatorcontrib><creatorcontrib>Shimoyama, Yusuke</creatorcontrib><creatorcontrib>Onodera, Motoyuki</creatorcontrib><creatorcontrib>Moroi, Rintaro</creatorcontrib><creatorcontrib>Kuroha, Masatake</creatorcontrib><creatorcontrib>Kanazawa, Yoshitake</creatorcontrib><creatorcontrib>Kimura, Tomoya</creatorcontrib><creatorcontrib>Shiga, Hisashi</creatorcontrib><creatorcontrib>Endo, Katsuya</creatorcontrib><creatorcontrib>Negoro, Kenichi</creatorcontrib><creatorcontrib>Yasuda, Jun</creatorcontrib><creatorcontrib>Esaki, Motohiro</creatorcontrib><creatorcontrib>Tokunaga, Katsushi</creatorcontrib><creatorcontrib>Nakamura, Minoru</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>McGovern, Dermot P B</creatorcontrib><creatorcontrib>Nagasaki, Masao</creatorcontrib><creatorcontrib>Kinouchi, Yoshitaka</creatorcontrib><creatorcontrib>Shimosegawa, Tooru</creatorcontrib><creatorcontrib>Masamune, Atsushi</creatorcontrib><title>A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals</title><title>Journal of Crohn's and colitis</title><addtitle>J Crohns Colitis</addtitle><description>Abstract Background and Aims Genome-wide association studies [GWASs] of European populations have identified numerous susceptibility loci for Crohn’s disease [CD]. Susceptibility genes differ by ethnicity, however, so GWASs specific for Asian populations are required. This study aimed to clarify the Japanese-specific genetic background for CD by a GWAS using the Japonica array [JPA] and subsequent imputation with the 1KJPN reference panel. Methods Two independent Japanese case/control sets (Tohoku region [379 CD patients, 1621 controls] and Kyushu region [334 CD patients, 462 controls]) were included. GWASs were performed separately for each population, followed by a meta-analysis. Two additional replication sets [254 + 516 CD patients and 287 + 565 controls] were analysed for top hit single nucleotide polymorphisms [SNPs] from novel genomic regions. Results Genotype data of 4 335 144 SNPs from 713 Japanese CD patients and 2083 controls were analysed. SNPs located in TNFSF15 (rs78898421, Pmeta = 2.59 × 10−26, odds ratio [OR] = 2.10), HLA-DQB1 [rs184950714, pmeta = 3.56 × 10−19, OR = 2.05], ZNF365, and 4p14 loci were significantly associated with CD in Japanese individuals. Replication analyses were performed for four novel candidate loci [p &lt;1 × 10−6], and rs488200 located upstream of RAP1A was significantly associated with CD [pcombined = 4.36 × 10−8, OR = 1.31]. Transcriptome analysis of CD4+ effector memory T cells from lamina propria mononuclear cells of CD patients revealed a significant association of rs488200 with RAP1A expression. Conclusions RAP1A is a novel susceptibility locus for CD in the Japanese population.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - genetics</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genome-Wide Association Study</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Original</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>rap1 GTP-Binding Proteins - genetics</subject><subject>rap1 GTP-Binding Proteins - physiology</subject><subject>Young Adult</subject><issn>1873-9946</issn><issn>1876-4479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFu1DAURS1ERUthzQ55iZDSsWO7jjdI0QBlqgoQw95ynOfWo4wd4mRQNojf4Pf4EjydUhWJ1buS7zt-VxehF5ScUaLYAqyNxcbaxWYzUyUfoRNayfOCc6ke32pWKMXPj9HTlDaECCVk9QQdMyIIqSQ_QT9qfAEhbqH47lvAdUrRejP6GPB6nNoZr1oIo3ezD9f4S_2Z1tgkbPDHuIMOr6dkoR994zs_znsSYBcHvBziTfj981fCb30CkwD7gC9NbwJkvQqt3_l2Ml16ho5cHvD8bp6i9ft3X5cfiqtPF6tlfVVYrvhYMMpJyavGCccVSEZFQ5mSTkFr94qZxklpLFFECmcrSirLZduWQKwQ7BS9OVD7qdnmlZxoMJ3uB781w6yj8frfl-Bv9HXcaclFVUqZAa_uAEP8NkEa9dbn5F2XA8Up6ZJyRUqmFMvWxcFqh5jSAO7-G0r0vjO970znzvShs7zx8uF19_6_JWXD64MhTv1_acUD2h8hS6aE</recordid><startdate>20190426</startdate><enddate>20190426</enddate><creator>Kakuta, Yoichi</creator><creator>Kawai, Yosuke</creator><creator>Naito, Takeo</creator><creator>Hirano, Atsushi</creator><creator>Umeno, Junji</creator><creator>Fuyuno, Yuta</creator><creator>Liu, Zhenqiu</creator><creator>Li, Dalin</creator><creator>Nakano, Takeru</creator><creator>Izumiyama, Yasuhiro</creator><creator>Ichikawa, Ryo</creator><creator>Okamoto, Daisuke</creator><creator>Nagai, Hiroshi</creator><creator>Matsumoto, Shin</creator><creator>Yamamoto, Katsutoshi</creator><creator>Yokoyama, Naonobu</creator><creator>Chiba, Hirofumi</creator><creator>Shimoyama, Yusuke</creator><creator>Onodera, Motoyuki</creator><creator>Moroi, Rintaro</creator><creator>Kuroha, Masatake</creator><creator>Kanazawa, Yoshitake</creator><creator>Kimura, Tomoya</creator><creator>Shiga, Hisashi</creator><creator>Endo, Katsuya</creator><creator>Negoro, Kenichi</creator><creator>Yasuda, Jun</creator><creator>Esaki, Motohiro</creator><creator>Tokunaga, Katsushi</creator><creator>Nakamura, Minoru</creator><creator>Matsumoto, Takayuki</creator><creator>McGovern, Dermot P B</creator><creator>Nagasaki, Masao</creator><creator>Kinouchi, Yoshitaka</creator><creator>Shimosegawa, Tooru</creator><creator>Masamune, Atsushi</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190426</creationdate><title>A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals</title><author>Kakuta, Yoichi ; Kawai, Yosuke ; Naito, Takeo ; Hirano, Atsushi ; Umeno, Junji ; Fuyuno, Yuta ; Liu, Zhenqiu ; Li, Dalin ; Nakano, Takeru ; Izumiyama, Yasuhiro ; Ichikawa, Ryo ; Okamoto, Daisuke ; Nagai, Hiroshi ; Matsumoto, Shin ; Yamamoto, Katsutoshi ; Yokoyama, Naonobu ; Chiba, Hirofumi ; Shimoyama, Yusuke ; Onodera, Motoyuki ; Moroi, Rintaro ; Kuroha, Masatake ; Kanazawa, Yoshitake ; Kimura, Tomoya ; Shiga, Hisashi ; Endo, Katsuya ; Negoro, Kenichi ; Yasuda, Jun ; Esaki, Motohiro ; Tokunaga, Katsushi ; Nakamura, Minoru ; Matsumoto, Takayuki ; McGovern, Dermot P B ; Nagasaki, Masao ; Kinouchi, Yoshitaka ; Shimosegawa, Tooru ; Masamune, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-3140248bf5f49e7315b1397f9edcb1393abf77ac09075fc8108c47dd2e0c553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn Disease - genetics</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genome-Wide Association Study</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Original</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>rap1 GTP-Binding Proteins - genetics</topic><topic>rap1 GTP-Binding Proteins - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kakuta, Yoichi</creatorcontrib><creatorcontrib>Kawai, Yosuke</creatorcontrib><creatorcontrib>Naito, Takeo</creatorcontrib><creatorcontrib>Hirano, Atsushi</creatorcontrib><creatorcontrib>Umeno, Junji</creatorcontrib><creatorcontrib>Fuyuno, Yuta</creatorcontrib><creatorcontrib>Liu, Zhenqiu</creatorcontrib><creatorcontrib>Li, Dalin</creatorcontrib><creatorcontrib>Nakano, Takeru</creatorcontrib><creatorcontrib>Izumiyama, Yasuhiro</creatorcontrib><creatorcontrib>Ichikawa, Ryo</creatorcontrib><creatorcontrib>Okamoto, Daisuke</creatorcontrib><creatorcontrib>Nagai, Hiroshi</creatorcontrib><creatorcontrib>Matsumoto, Shin</creatorcontrib><creatorcontrib>Yamamoto, Katsutoshi</creatorcontrib><creatorcontrib>Yokoyama, Naonobu</creatorcontrib><creatorcontrib>Chiba, Hirofumi</creatorcontrib><creatorcontrib>Shimoyama, Yusuke</creatorcontrib><creatorcontrib>Onodera, Motoyuki</creatorcontrib><creatorcontrib>Moroi, Rintaro</creatorcontrib><creatorcontrib>Kuroha, Masatake</creatorcontrib><creatorcontrib>Kanazawa, Yoshitake</creatorcontrib><creatorcontrib>Kimura, Tomoya</creatorcontrib><creatorcontrib>Shiga, Hisashi</creatorcontrib><creatorcontrib>Endo, Katsuya</creatorcontrib><creatorcontrib>Negoro, Kenichi</creatorcontrib><creatorcontrib>Yasuda, Jun</creatorcontrib><creatorcontrib>Esaki, Motohiro</creatorcontrib><creatorcontrib>Tokunaga, Katsushi</creatorcontrib><creatorcontrib>Nakamura, Minoru</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>McGovern, Dermot P B</creatorcontrib><creatorcontrib>Nagasaki, Masao</creatorcontrib><creatorcontrib>Kinouchi, Yoshitaka</creatorcontrib><creatorcontrib>Shimosegawa, Tooru</creatorcontrib><creatorcontrib>Masamune, Atsushi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Crohn's and colitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kakuta, Yoichi</au><au>Kawai, Yosuke</au><au>Naito, Takeo</au><au>Hirano, Atsushi</au><au>Umeno, Junji</au><au>Fuyuno, Yuta</au><au>Liu, Zhenqiu</au><au>Li, Dalin</au><au>Nakano, Takeru</au><au>Izumiyama, Yasuhiro</au><au>Ichikawa, Ryo</au><au>Okamoto, Daisuke</au><au>Nagai, Hiroshi</au><au>Matsumoto, Shin</au><au>Yamamoto, Katsutoshi</au><au>Yokoyama, Naonobu</au><au>Chiba, Hirofumi</au><au>Shimoyama, Yusuke</au><au>Onodera, Motoyuki</au><au>Moroi, Rintaro</au><au>Kuroha, Masatake</au><au>Kanazawa, Yoshitake</au><au>Kimura, Tomoya</au><au>Shiga, Hisashi</au><au>Endo, Katsuya</au><au>Negoro, Kenichi</au><au>Yasuda, Jun</au><au>Esaki, Motohiro</au><au>Tokunaga, Katsushi</au><au>Nakamura, Minoru</au><au>Matsumoto, Takayuki</au><au>McGovern, Dermot P B</au><au>Nagasaki, Masao</au><au>Kinouchi, Yoshitaka</au><au>Shimosegawa, Tooru</au><au>Masamune, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals</atitle><jtitle>Journal of Crohn's and colitis</jtitle><addtitle>J Crohns Colitis</addtitle><date>2019-04-26</date><risdate>2019</risdate><volume>13</volume><issue>5</issue><spage>648</spage><epage>658</epage><pages>648-658</pages><issn>1873-9946</issn><eissn>1876-4479</eissn><abstract>Abstract Background and Aims Genome-wide association studies [GWASs] of European populations have identified numerous susceptibility loci for Crohn’s disease [CD]. Susceptibility genes differ by ethnicity, however, so GWASs specific for Asian populations are required. This study aimed to clarify the Japanese-specific genetic background for CD by a GWAS using the Japonica array [JPA] and subsequent imputation with the 1KJPN reference panel. Methods Two independent Japanese case/control sets (Tohoku region [379 CD patients, 1621 controls] and Kyushu region [334 CD patients, 462 controls]) were included. GWASs were performed separately for each population, followed by a meta-analysis. Two additional replication sets [254 + 516 CD patients and 287 + 565 controls] were analysed for top hit single nucleotide polymorphisms [SNPs] from novel genomic regions. Results Genotype data of 4 335 144 SNPs from 713 Japanese CD patients and 2083 controls were analysed. SNPs located in TNFSF15 (rs78898421, Pmeta = 2.59 × 10−26, odds ratio [OR] = 2.10), HLA-DQB1 [rs184950714, pmeta = 3.56 × 10−19, OR = 2.05], ZNF365, and 4p14 loci were significantly associated with CD in Japanese individuals. Replication analyses were performed for four novel candidate loci [p &lt;1 × 10−6], and rs488200 located upstream of RAP1A was significantly associated with CD [pcombined = 4.36 × 10−8, OR = 1.31]. Transcriptome analysis of CD4+ effector memory T cells from lamina propria mononuclear cells of CD patients revealed a significant association of rs488200 with RAP1A expression. Conclusions RAP1A is a novel susceptibility locus for CD in the Japanese population.</abstract><cop>UK</cop><pub>Oxford University Press</pub><pmid>30500874</pmid><doi>10.1093/ecco-jcc/jjy197</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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ispartof Journal of Crohn's and colitis, 2019-04, Vol.13 (5), p.648-658
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1876-4479
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source Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection
subjects Adult
Case-Control Studies
Crohn Disease - epidemiology
Crohn Disease - genetics
Female
Gene Expression Profiling
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Humans
Japan - epidemiology
Male
Original
Polymorphism, Single Nucleotide - genetics
rap1 GTP-Binding Proteins - genetics
rap1 GTP-Binding Proteins - physiology
Young Adult
title A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals
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