Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes

Effects of Diet versus Gastric Bypass on Metabolic Function in Diabetes

This study evaluated the metabolic effects of Roux-en-Y gastric bypass or diet alone in patients with diabetes who had lost matched amounts of weight. The primary outcome, the change in hepatic insulin sensitivity, was similar in the two groups. Thus, weight loss itself, not effects independent of w...

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Veröffentlicht in:The New England journal of medicine 2020-08, Vol.383 (8), p.721-732
Hauptverfasser: Yoshino, Mihoko, Kayser, Brandon D, Yoshino, Jun, Stein, Richard I, Reeds, Dominic, Eagon, J. Christopher, Eckhouse, Shaina R, Watrous, Jeramie D, Jain, Mohit, Knight, Rob, Schechtman, Kenneth, Patterson, Bruce W, Klein, Samuel
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Beta cells
Blood Glucose - analysis
Blood Glucose - metabolism
Body composition
Body weight loss
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diet therapy
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - surgery
Diet
Fat-free body mass
Fatty acids
Female
Gastric Bypass
Gastrointestinal surgery
Glucose
Glucose Clamp Technique
Hemoglobin
Homeostasis
Humans
Insulin
Insulin - metabolism
Insulin resistance
Insulin Resistance - physiology
Male
Meals
Metabolism
Middle Aged
Obesity
Obesity - complications
Obesity - diet therapy
Obesity - surgery
Pancreas
Plasma
Prospective Studies
Remission Induction
Surgery
Weight control
Weight Loss - physiology
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Beschreibung
Zusammenfassung:This study evaluated the metabolic effects of Roux-en-Y gastric bypass or diet alone in patients with diabetes who had lost matched amounts of weight. The primary outcome, the change in hepatic insulin sensitivity, was similar in the two groups. Thus, weight loss itself, not effects independent of weight loss, accounted for the results.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa2003697