Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial

Abstract We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be ind...

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Veröffentlicht in:	Clinical infectious diseases 2020-01, Vol.70 (3), p.525-527
Hauptverfasser:	Oldenburg, Catherine E, Hinterwirth, Armin, Sié, Ali, Coulibaly, Boubacar, Ouermi, Lucienne, Dah, Clarisse, Tapsoba, Charlemagne, Cummings, Susie L, Zhong, Lina, Chen, Cindi, Sarkar, Samarpita, Bärnighausen, Till, Lietman, Thomas M, Keenan, Jeremy D, Doan, Thuy
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Azithromycin Brief Reports Burkina Faso Child, Preschool Gastrointestinal Microbiome Humans Infant Macrolides
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