Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial

Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial

Abstract We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be ind...

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Veröffentlicht in:Clinical infectious diseases 2020-01, Vol.70 (3), p.525-527
Hauptverfasser: Oldenburg, Catherine E, Hinterwirth, Armin, Sié, Ali, Coulibaly, Boubacar, Ouermi, Lucienne, Dah, Clarisse, Tapsoba, Charlemagne, Cummings, Susie L, Zhong, Lina, Chen, Cindi, Sarkar, Samarpita, Bärnighausen, Till, Lietman, Thomas M, Keenan, Jeremy D, Doan, Thuy
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - therapeutic use
Azithromycin
Brief Reports
Burkina Faso
Child, Preschool
Gastrointestinal Microbiome
Humans
Infant
Macrolides
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Zusammenfassung:Abstract We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciz455