Enhancing catalytic alkane hydroxylation by tuning the outer coordination sphere in a heme-containing metal–organic framework† †Electronic supplementary information (ESI) available: Experimental details and characterization data for all new compounds; crystallographic data for 1, 1FeCl, and 2; detailed results of catalytic cyclohexane oxidation reactions. CCDC 1992907–1992909. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d0sc01796e

Removing labile protons via acetylation of the structural nodes in a metal–organic framework enhances catalysis at the heme linkers. Catalytic heme active sites of enzymes are sequestered by the protein superstructure and are regulated by precisely defined outer coordination spheres. Here, we emulate these protective functions in the porphyrinic metal–organic framework PCN-224 by post-synthetic acetylation and subsequent hydroxylation of the Zr 6 nodes. A suite of physical methods demonstrates that both transformations preserve framework structure, crystallinity, and porosity without modifying the inner coordination spheres of the iron sites. Single-crystal X-ray analyses establish that acetylation replaces the mixture of formate, benzoate, aqua, and terminal hydroxo ligands at the Zr 6 nodes with acetate ligands, and hydroxylation affords nodes with seven-coordinate, hydroxo-terminated Zr 4+ ions. The chemical influence of these reactions is probed with heme-catalyzed cyclohexane hydroxylation as a model reaction. By virtue of passivated reactive sites at the Zr 6 nodes, the acetylated framework oxidizes cyclohexane with a yield of 68(8)%, 2.6-fold higher than in the hydroxylated framework, and an alcohol/ketone ratio of 5.6(3).