IDH Mutations in AML Patients; A higher Association with Intermediate Risk Cytogenetics

IDH mutations diversely affect the prognosis of cyogenetically normal acute myeloid leukemia (CN-AML) adult patients. The aim of this study is to assess the frequency of IDH mutations and to evaluate its role in AML prognosis. We have analyzed IDH1 and 2 mutations using High Resolution Melting curve...

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Veröffentlicht in:Asian Pacific Journal of Cancer Prevention 2020-03, Vol.21 (3), p.721-725
Hauptverfasser: ElNahass, Yasser H, Badawy, Ragia H, ElRefaey, Fatma A, Nooh, Hend A, Ibrahiem, Dalia, Nader, Heba A, Mahmoud, Hossam K, ElMetnawy, Wafaa H
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Sprache:eng
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Zusammenfassung:IDH mutations diversely affect the prognosis of cyogenetically normal acute myeloid leukemia (CN-AML) adult patients. The aim of this study is to assess the frequency of IDH mutations and to evaluate its role in AML prognosis. We have analyzed IDH1 and 2 mutations using High Resolution Melting curve analysis (HRM) in 70 denovo AML patients. The median age of AML patients is 40 years (16-75). Incidence of IDH mutations is 10/70 (14.3%); 2 (2.9%) IDH1 mutant and 8 (11.4%) IDH2 mutant. Median PB blasts of mutant IDH patients was 67.5% (25-96) vs. 44% (0-98) for wild type (p=0.065). Eight/10 (80%) mutant IDH patients had B.M blasts ≥50% vs. 2/10 (20%)
ISSN:2476-762X
1513-7368
2476-762X
DOI:10.31557/APJCP.2020.21.3.721