Photodynamic and sonodynamic therapy of acute hypoxemic respiratory failure in patients with COVID-19

•COVID-19 is largely localized in lungs.•SARS-CoV-2 binds to the heme groups in hemoglobin that leads to severe hypoxia.•Porphyrin-based photosensitizers (PS) act as a ‘decoy’ in which the SARS-CoV-2 virions would attach to PS molecules.•Photoactivation capable of destroying the bonded SARS-CoV-2 vi...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2020-09, Vol.31, p.101961-101961, Article 101961
Hauptverfasser:	Kipshidze, Nicholas, Yeo, Nicholas, Kipshidze, Nodar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Cause of Death Coronavirus Infections - complications Coronavirus Infections - diagnosis Coronavirus Infections - drug therapy COVID-19 Critical Illness - mortality Disease Progression Female Humans Hypoxia - drug therapy Hypoxia - etiology Letter to the Editor Male Pandemics - statistics & numerical data Photochemotherapy - methods Pneumonia, Viral - complications Pneumonia, Viral - diagnosis Pneumonia, Viral - drug therapy Respiratory Insufficiency - drug therapy Risk Assessment Severe Acute Respiratory Syndrome - diagnosis Severe Acute Respiratory Syndrome - drug therapy Severe Acute Respiratory Syndrome - epidemiology Survival Analysis
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Beschreibung
Zusammenfassung:	•COVID-19 is largely localized in lungs.•SARS-CoV-2 binds to the heme groups in hemoglobin that leads to severe hypoxia.•Porphyrin-based photosensitizers (PS) act as a ‘decoy’ in which the SARS-CoV-2 virions would attach to PS molecules.•Photoactivation capable of destroying the bonded SARS-CoV-2 virions.
ISSN:	1572-1000 1873-1597 1873-1597
DOI:	10.1016/j.pdpdt.2020.101961