Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Autopsy examination of lungs from seven patients who died from Covid-19 showed intussusceptive angiogenesis in greater profusion than was found in lungs from patients who died from influenza or in uninfected lungs that were rejected for transplantation.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2020-07, Vol.383 (2), p.120-128
Hauptverfasser:	Ackermann, Maximilian, Verleden, Stijn E, Kuehnel, Mark, Haverich, Axel, Welte, Tobias, Laenger, Florian, Vanstapel, Arno, Werlein, Christopher, Stark, Helge, Tzankov, Alexandar, Li, William W, Li, Vincent W, Mentzer, Steven J, Jonigk, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Alveoli Angiogenesis Autopsy Betacoronavirus Cell membranes Computed tomography Coronavirus Infections - mortality Coronavirus Infections - pathology Coronaviruses COVID-19 Disease transmission Edema Endothelium Endothelium, Vascular - pathology Endothelium, Vascular - virology Female Gene expression General & Internal Medicine Humans Infections Inflammation Influenza Influenza A Influenza A Virus, H1N1 Subtype Influenza, Human - mortality Influenza, Human - pathology Life Sciences & Biomedicine Lung - pathology Lungs Lymphocytes Lymphocytes T Male Medicine, General & Internal Middle Aged Neovascularization, Pathologic Pandemics Pneumonia Pneumonia, Viral - mortality Pneumonia, Viral - pathology Pulmonary arteries Respiration Respiratory diseases Respiratory distress syndrome Respiratory Distress Syndrome - pathology Respiratory Distress Syndrome - virology Respiratory failure Respiratory Insufficiency SARS-CoV-2 Scanning electron microscopy Science & Technology Severe acute respiratory syndrome coronavirus 2 Thrombosis Thrombosis - virology
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Beschreibung
Zusammenfassung:	Autopsy examination of lungs from seven patients who died from Covid-19 showed intussusceptive angiogenesis in greater profusion than was found in lungs from patients who died from influenza or in uninfected lungs that were rejected for transplantation.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2015432