COVID‐19 and coagulation dysfunction in adults: A systematic review and meta‐analysis

The outbreak of 2019 novel coronavirus disease (COVID‐19) has posed a grave threat to the global public health. The COVID‐19‐induced infection is closely related to coagulation dysfunction in the affected patients. This paper attempts to conduct a meta‐analysis and systematically review the blood co...

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Veröffentlicht in:	Journal of medical virology 2021-02, Vol.93 (2), p.934-944
Hauptverfasser:	Lin, Jing, Yan, Han, Chen, Hanchuan, He, Chen, Lin, Chunjin, He, Haoming, Zhang, Sicheng, Shi, Songjing, Lin, Kaiyang
Format:	Artikel
Sprache:	eng
Schlagworte:	2019 novel coronavirus disease Blood coagulation Blood Coagulation Disorders - virology Blood Platelets Coagulation Confidence intervals Coronaviruses Correlation analysis COVID-19 COVID-19 - complications Dimers Fibrin Fibrinogen Degradation Products - analysis Fibrinogen Fibrinogen - analysis Hospitalization Humans Indicators Meta-analysis Partial Thromboplastin Time Patients Platelets Prognosis Prothrombin Public health Risk Risk Factors severity Severity of Illness Index Thromboplastin Viral diseases Virology
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Zusammenfassung:	The outbreak of 2019 novel coronavirus disease (COVID‐19) has posed a grave threat to the global public health. The COVID‐19‐induced infection is closely related to coagulation dysfunction in the affected patients. This paper attempts to conduct a meta‐analysis and systematically review the blood coagulation indicators in patients with severe COVID‐19. A meta‐analysis of eligible studies was performed to compare the blood coagulation indicators in patients with severe and nonsevere COVID‐19. PubMed, Embase, Web of Science, and the Cochrane Library were searched for studies published between 1 December 2019 and 7 May 2020. A total of 13 studies with 1341 adult patients were enrolled in this analysis. Platelet (weighted mean difference [WMD] = −24.83, 95% confidence interval [CI]: −34.12 to −15.54; P
ISSN:	0146-6615 1096-9071
DOI:	10.1002/jmv.26346