The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A

This study aimed to identify prostaglandin synthases (PGS) that mediate bisphenol A (BPA)-induced prostatic hyperplasia and explore their underlying mechanisms. In an in vivo study, male adult Sprague–Dawley rats were treated with different concentrations of BPA (10, 30, 90, or 270 μg/kg, i.g., dail...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), p.13108, Article 13108
Hauptverfasser:	Wu, Shuangshuang, Huang, Dongyan, Su, Xin, Yan, Han, Ma, Aicui, Li, Lei, Wu, Jianhui, Sun, Zuyue
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol 631/154/570 631/337 Androgen receptors Animals Apoptosis Apoptosis - drug effects Benzhydryl Compounds - pharmacology Bisphenol A Cell growth Cell proliferation Cell Proliferation - drug effects Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Dose-Response Relationship, Drug Epithelial cells Estradiol - blood Estrogen Receptor alpha - metabolism Fibroblasts Gene Expression Regulation, Enzymologic - drug effects Humanities and Social Sciences Hyperplasia Intramolecular Oxidoreductases - metabolism Lipocalin Lipocalins - metabolism Male multidisciplinary NF-κB protein Phenols - pharmacology Proliferating cell nuclear antigen Prostaglandin D2 synthase Prostaglandin-Endoperoxide Synthases - metabolism Prostate Prostatic Hyperplasia - blood Prostatic Hyperplasia - chemically induced Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Rats Rats, Sprague-Dawley Receptors, Androgen - metabolism Science Science (multidisciplinary) Testosterone Testosterone - blood
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Zusammenfassung:	This study aimed to identify prostaglandin synthases (PGS) that mediate bisphenol A (BPA)-induced prostatic hyperplasia and explore their underlying mechanisms. In an in vivo study, male adult Sprague–Dawley rats were treated with different concentrations of BPA (10, 30, 90, or 270 μg/kg, i.g., daily), or with vehicle for 4 weeks. Results revealed that low-dose BPA induced prostatic hyperplasia with increased PCNA/TUNEL ratio. It significantly upregulated the expression of cyclooxygenase-2 (COX-2) and NF-κB in the dorsolateral prostate ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-69809-y