Effect of heat-inactivated Lactobacillus paracasei N1115 on microbiota and gut-brain axis related molecules

Effect of heat-inactivated Lactobacillus paracasei N1115 on microbiota and gut-brain axis related molecules

This study was conducted to evaluate the possibility of using heated-inactivated lactobacilli to protect neonates from harmful effects of antibiotics. Thirty neonate mice were randomly divided into three groups of ten and treated with either sterilized water, an antibiotics cocktail, or the same ant...

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Veröffentlicht in:Bioscience of Microbiota, Food and Health Food and Health, 2020, Vol.39(3), pp.89-99
Hauptverfasser: ZHANG, Yujie, PU, Fangfang, CHENG, Ruyue, GUO, Jiawen, SHEN, Xi, WANG, Shijie, ZHU, Hong, ZHANG, Xiao, CHENG, Guo, LI, Ming, HE, Fang
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Brain
Brain-derived neurotrophic factor
Corticosterone
Crypts
Dysbacteriosis
Fecal microflora
gut microbiota
Heat
heat-inactivated lactobacilli
Interleukin 6
Lactobacilli
Lactobacillus paracasei
Microbiota
Neonates
Prefrontal cortex
Serotonin
Serotonin S1 receptors
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Zusammenfassung:This study was conducted to evaluate the possibility of using heated-inactivated lactobacilli to protect neonates from harmful effects of antibiotics. Thirty neonate mice were randomly divided into three groups of ten and treated with either sterilized water, an antibiotics cocktail, or the same antibiotics plus heat-inactivated Lactobacillus paracasei N1115. The administration of antibiotics significantly increased the serum interleukin-6 (IL-6) levels of the tested mice (p
ISSN:2186-3342
2186-6953
2186-3342
DOI:10.12938/bmfh.2019-025