Cyclic AMP in human preterm infant blood is associated with increased TLR-mediated production of acute-phase and anti-inflammatory cytokines in vitro

Cyclic AMP in human preterm infant blood is associated with increased TLR-mediated production of acute-phase and anti-inflammatory cytokines in vitro

Background Preterm infants are at high risk of infection and have distinct pathogen recognition responses. Suggested mechanisms include soluble mediators that enhance cellular levels of cAMP. The aim of this study was to assess the relationship between blood cAMP concentrations and TLR-mediated cyto...

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Veröffentlicht in:Pediatric research 2020-11, Vol.88 (5), p.717-725
Hauptverfasser: Strunk, Tobias, van Haren, Simon D., Hibbert, Julie, Pettengill, Matthew, Ozonoff, Al, Jans, Jop, Schüller, Simone S., Burgner, David, Levy, Ofer, Currie, Andrew J.
Format: Artikel
Sprache:eng
Schlagworte:
Basic Science Article
Cytokines
Medicine
Medicine & Public Health
Newborn babies
Pathogens
Pediatric Surgery
Pediatrics
Premature babies
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Zusammenfassung:Background Preterm infants are at high risk of infection and have distinct pathogen recognition responses. Suggested mechanisms include soluble mediators that enhance cellular levels of cAMP. The aim of this study was to assess the relationship between blood cAMP concentrations and TLR-mediated cytokine production in infants during the first month of life. Methods Cord and serial peripheral blood samples (days of life 1–28) were obtained from a cohort of very preterm (
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-019-0586-2