T cell responses in patients with COVID-19

The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting...

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Veröffentlicht in:	Nature reviews. Immunology 2020-09, Vol.20 (9), p.529-536
Hauptverfasser:	Chen, Zeyu, John Wherry, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/2152/1566 631/326/596/4130 B cells Biomedical and Life Sciences Biomedicine Coronaviruses COVID-19 Health aspects Immune response Immunology Lymphocytes Lymphocytes T Medical colleges Phenotypes Progress Severe acute respiratory syndrome coronavirus 2 T cells
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Beschreibung
Zusammenfassung:	The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting to enable some general concepts to emerge. In this Progress article, Zeyu Chen and E. John Wherry summarize early reports of the T cell responses observed in patients with COVID-19, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.
ISSN:	1474-1733 1474-1741
DOI:	10.1038/s41577-020-0402-6