Evaluation of the ceiling levels of ortho‐phthalaldehyde exposure among health care workers engaged in endoscope disinfection: A new methodology using video‐exposure monitoring
Objectives The present study aimed to develop a method for measuring the ceiling level of ortho‐phthalaldehyde (OPA) exposure and evaluate the ceiling levels of OPA exposure among health care workers who handle disinfectant solutions containing OPA for the disinfection of endoscopes. Methods The stu...
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| Veröffentlicht in: | Journal of occupational health 2020-01, Vol.62 (1), p.e12139-n/a |
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| creator | Yamamoto, Shinobu Hachiya, Yuriko Yuasa, Eri Takeuchi, Akito Ishidao, Toru Mihara, Mitsuhisa Terauchi, Yasuhiro Ichiba, Masayoshi Hori, Hajime |
| description | Objectives
The present study aimed to develop a method for measuring the ceiling level of ortho‐phthalaldehyde (OPA) exposure and evaluate the ceiling levels of OPA exposure among health care workers who handle disinfectant solutions containing OPA for the disinfection of endoscopes.
Methods
The study consisted of a preliminary survey and main survey. In the preliminary survey, processes involving high‐concentration exposure to OPA were identified by video‐exposure monitoring (VEM). In the main survey, the ceiling levels of OPA exposure for high‐concentration exposure processes identified from the results of the preliminary survey were determined using a measuring method combining sampling using a 2,4‐dinitrophenylhydrazine‐silica cartridge and analysis by high‐performance liquid chromatography tandem mass spectrometry.
Results
In the preliminary survey, seven processes involving high‐concentration exposure to OPA were identified by VEM. The duration of each process was short, lasting from 20 seconds to a few minutes. In the main survey, the OPA concentrations for the identified high‐concentration exposure processes ranged from 1.18 to 4.49 ppb, which markedly exceeded the threshold limit value ceiling (TLV‐C) of 0.1 ppb recommended by the American Conference of Governmental Industrial Hygienists.
Conclusions
The method for measuring the ceiling level of OPA exposure was established using VEM and the highly sensitive method of chemical analysis; and we successfully evaluated the ceiling levels of OPA exposure among health care workers engaged in endoscope disinfection. This approach can also be applied to other chemical substances with recommended TLV‐Cs, and important information for reducing exposure can thus be obtained. |
| doi_str_mv | 10.1002/1348-9585.12139 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7382765</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2472960001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5319-d24efa0f5751484de99a641e82eb919a4f0441e7ce0a5303bbfdb1c1130f61263</originalsourceid><addsrcrecordid>eNqFkU1uFDEQhS0EIiGwZocssZ7EP_1nFkhRFBJQpGxgbbntcreDp93Y3TPMjiNwmJyIk-BmwiisWLlc9fy-kh9Cryk5pYSwM8qLZiXKpjyljHLxBB0fOk8f1UfoRUp3hHDGG_4cHXFWU05KcYzuLzfKz2pyYcDB4qkHrMF5N3TYwwZ8WrohTn349ePn2E-98sob6HcGMHwfQ5ojYLUOWd-D8lOPtcqdbYhfISYMQ6c6MNgNuTQh6TACNi65wYJeoO_wOR5gi9eQESb40O3wnBb8xhlYoAdKhrgpxDx7iZ5Z5RO8ejhP0JcPl58vrlc3t1cfL85vVrrkVKwMK8AqYsu6pEVTGBBCVQWFhkErqFCFJUW-1hqIKjnhbWtNSzXNX2Mryip-gt7vfce5XYPRMExReTlGt1ZxJ4Ny8t_J4HrZhY2secPqqswGbx8MYvg2Q5rkXZjjkHeWrKiZqAghNKvO9iodQ0oR7IFAiVxilkuQcglS_ok5v3jzeLGD_m-uWVDtBVvnYfc_P_np9prtnX8DOG26QA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2472960001</pqid></control><display><type>article</type><title>Evaluation of the ceiling levels of ortho‐phthalaldehyde exposure among health care workers engaged in endoscope disinfection: A new methodology using video‐exposure monitoring</title><source>Oxford Journals Open Access Collection</source><source>J-STAGE Free</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Yamamoto, Shinobu ; Hachiya, Yuriko ; Yuasa, Eri ; Takeuchi, Akito ; Ishidao, Toru ; Mihara, Mitsuhisa ; Terauchi, Yasuhiro ; Ichiba, Masayoshi ; Hori, Hajime</creator><creatorcontrib>Yamamoto, Shinobu ; Hachiya, Yuriko ; Yuasa, Eri ; Takeuchi, Akito ; Ishidao, Toru ; Mihara, Mitsuhisa ; Terauchi, Yasuhiro ; Ichiba, Masayoshi ; Hori, Hajime</creatorcontrib><description>Objectives
The present study aimed to develop a method for measuring the ceiling level of ortho‐phthalaldehyde (OPA) exposure and evaluate the ceiling levels of OPA exposure among health care workers who handle disinfectant solutions containing OPA for the disinfection of endoscopes.
Methods
The study consisted of a preliminary survey and main survey. In the preliminary survey, processes involving high‐concentration exposure to OPA were identified by video‐exposure monitoring (VEM). In the main survey, the ceiling levels of OPA exposure for high‐concentration exposure processes identified from the results of the preliminary survey were determined using a measuring method combining sampling using a 2,4‐dinitrophenylhydrazine‐silica cartridge and analysis by high‐performance liquid chromatography tandem mass spectrometry.
Results
In the preliminary survey, seven processes involving high‐concentration exposure to OPA were identified by VEM. The duration of each process was short, lasting from 20 seconds to a few minutes. In the main survey, the OPA concentrations for the identified high‐concentration exposure processes ranged from 1.18 to 4.49 ppb, which markedly exceeded the threshold limit value ceiling (TLV‐C) of 0.1 ppb recommended by the American Conference of Governmental Industrial Hygienists.
Conclusions
The method for measuring the ceiling level of OPA exposure was established using VEM and the highly sensitive method of chemical analysis; and we successfully evaluated the ceiling levels of OPA exposure among health care workers engaged in endoscope disinfection. This approach can also be applied to other chemical substances with recommended TLV‐Cs, and important information for reducing exposure can thus be obtained.</description><identifier>ISSN: 1348-9585</identifier><identifier>ISSN: 1341-9145</identifier><identifier>EISSN: 1348-9585</identifier><identifier>DOI: 10.1002/1348-9585.12139</identifier><identifier>PMID: 32713059</identifier><language>eng</language><publisher>Australia: John Wiley & Sons, Inc</publisher><subject>Camcorders ; Cameras ; Cartridges ; Chemical analysis ; Chromatography ; Disinfectants ; Disinfectants - adverse effects ; Disinfectants - analysis ; Disinfection ; Disinfection & disinfectants ; endoscope ; Endoscopes ; Environmental Monitoring - methods ; Equipment Contamination - prevention & control ; Exposure ; Gas flow ; Health care ; Health Personnel ; Humans ; Inhalation Exposure ; Liquid chromatography ; Mass spectrometry ; Mass spectroscopy ; measurement method ; Measurement methods ; Medical personnel ; Monitoring ; o-Phthalaldehyde - adverse effects ; o-Phthalaldehyde - analysis ; Occupational exposure ; Occupational Exposure - analysis ; Occupational health ; Original ; ortho‐phthalaldehyde ; Polls & surveys ; Scientific imaging ; Sensors ; Silica ; Silicon dioxide ; Surveys and Questionnaires ; threshold limit value‐ceiling ; video exposure monitoring ; VOCs ; Volatile organic compounds ; Workers</subject><ispartof>Journal of occupational health, 2020-01, Vol.62 (1), p.e12139-n/a</ispartof><rights>2020 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health</rights><rights>2020 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5319-d24efa0f5751484de99a641e82eb919a4f0441e7ce0a5303bbfdb1c1130f61263</cites><orcidid>0000-0002-0523-1794 ; 0000-0003-1782-6565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382765/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382765/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32713059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Shinobu</creatorcontrib><creatorcontrib>Hachiya, Yuriko</creatorcontrib><creatorcontrib>Yuasa, Eri</creatorcontrib><creatorcontrib>Takeuchi, Akito</creatorcontrib><creatorcontrib>Ishidao, Toru</creatorcontrib><creatorcontrib>Mihara, Mitsuhisa</creatorcontrib><creatorcontrib>Terauchi, Yasuhiro</creatorcontrib><creatorcontrib>Ichiba, Masayoshi</creatorcontrib><creatorcontrib>Hori, Hajime</creatorcontrib><title>Evaluation of the ceiling levels of ortho‐phthalaldehyde exposure among health care workers engaged in endoscope disinfection: A new methodology using video‐exposure monitoring</title><title>Journal of occupational health</title><addtitle>J Occup Health</addtitle><description>Objectives
The present study aimed to develop a method for measuring the ceiling level of ortho‐phthalaldehyde (OPA) exposure and evaluate the ceiling levels of OPA exposure among health care workers who handle disinfectant solutions containing OPA for the disinfection of endoscopes.
Methods
The study consisted of a preliminary survey and main survey. In the preliminary survey, processes involving high‐concentration exposure to OPA were identified by video‐exposure monitoring (VEM). In the main survey, the ceiling levels of OPA exposure for high‐concentration exposure processes identified from the results of the preliminary survey were determined using a measuring method combining sampling using a 2,4‐dinitrophenylhydrazine‐silica cartridge and analysis by high‐performance liquid chromatography tandem mass spectrometry.
Results
In the preliminary survey, seven processes involving high‐concentration exposure to OPA were identified by VEM. The duration of each process was short, lasting from 20 seconds to a few minutes. In the main survey, the OPA concentrations for the identified high‐concentration exposure processes ranged from 1.18 to 4.49 ppb, which markedly exceeded the threshold limit value ceiling (TLV‐C) of 0.1 ppb recommended by the American Conference of Governmental Industrial Hygienists.
Conclusions
The method for measuring the ceiling level of OPA exposure was established using VEM and the highly sensitive method of chemical analysis; and we successfully evaluated the ceiling levels of OPA exposure among health care workers engaged in endoscope disinfection. This approach can also be applied to other chemical substances with recommended TLV‐Cs, and important information for reducing exposure can thus be obtained.</description><subject>Camcorders</subject><subject>Cameras</subject><subject>Cartridges</subject><subject>Chemical analysis</subject><subject>Chromatography</subject><subject>Disinfectants</subject><subject>Disinfectants - adverse effects</subject><subject>Disinfectants - analysis</subject><subject>Disinfection</subject><subject>Disinfection & disinfectants</subject><subject>endoscope</subject><subject>Endoscopes</subject><subject>Environmental Monitoring - methods</subject><subject>Equipment Contamination - prevention & control</subject><subject>Exposure</subject><subject>Gas flow</subject><subject>Health care</subject><subject>Health Personnel</subject><subject>Humans</subject><subject>Inhalation Exposure</subject><subject>Liquid chromatography</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>measurement method</subject><subject>Measurement methods</subject><subject>Medical personnel</subject><subject>Monitoring</subject><subject>o-Phthalaldehyde - adverse effects</subject><subject>o-Phthalaldehyde - analysis</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational health</subject><subject>Original</subject><subject>ortho‐phthalaldehyde</subject><subject>Polls & surveys</subject><subject>Scientific imaging</subject><subject>Sensors</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Surveys and Questionnaires</subject><subject>threshold limit value‐ceiling</subject><subject>video exposure monitoring</subject><subject>VOCs</subject><subject>Volatile organic 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Yuriko</creator><creator>Yuasa, Eri</creator><creator>Takeuchi, Akito</creator><creator>Ishidao, Toru</creator><creator>Mihara, Mitsuhisa</creator><creator>Terauchi, Yasuhiro</creator><creator>Ichiba, Masayoshi</creator><creator>Hori, Hajime</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons 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of the ceiling levels of ortho‐phthalaldehyde exposure among health care workers engaged in endoscope disinfection: A new methodology using video‐exposure monitoring</title><author>Yamamoto, Shinobu ; Hachiya, Yuriko ; Yuasa, Eri ; Takeuchi, Akito ; Ishidao, Toru ; Mihara, Mitsuhisa ; Terauchi, Yasuhiro ; Ichiba, Masayoshi ; Hori, Hajime</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5319-d24efa0f5751484de99a641e82eb919a4f0441e7ce0a5303bbfdb1c1130f61263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Camcorders</topic><topic>Cameras</topic><topic>Cartridges</topic><topic>Chemical analysis</topic><topic>Chromatography</topic><topic>Disinfectants</topic><topic>Disinfectants - adverse effects</topic><topic>Disinfectants - analysis</topic><topic>Disinfection</topic><topic>Disinfection & disinfectants</topic><topic>endoscope</topic><topic>Endoscopes</topic><topic>Environmental Monitoring - methods</topic><topic>Equipment Contamination - prevention & control</topic><topic>Exposure</topic><topic>Gas flow</topic><topic>Health care</topic><topic>Health Personnel</topic><topic>Humans</topic><topic>Inhalation Exposure</topic><topic>Liquid chromatography</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>measurement method</topic><topic>Measurement methods</topic><topic>Medical personnel</topic><topic>Monitoring</topic><topic>o-Phthalaldehyde - adverse effects</topic><topic>o-Phthalaldehyde - analysis</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational health</topic><topic>Original</topic><topic>ortho‐phthalaldehyde</topic><topic>Polls & surveys</topic><topic>Scientific imaging</topic><topic>Sensors</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>Surveys and Questionnaires</topic><topic>threshold limit value‐ceiling</topic><topic>video exposure monitoring</topic><topic>VOCs</topic><topic>Volatile organic compounds</topic><topic>Workers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Shinobu</creatorcontrib><creatorcontrib>Hachiya, Yuriko</creatorcontrib><creatorcontrib>Yuasa, Eri</creatorcontrib><creatorcontrib>Takeuchi, Akito</creatorcontrib><creatorcontrib>Ishidao, Toru</creatorcontrib><creatorcontrib>Mihara, Mitsuhisa</creatorcontrib><creatorcontrib>Terauchi, Yasuhiro</creatorcontrib><creatorcontrib>Ichiba, Masayoshi</creatorcontrib><creatorcontrib>Hori, Hajime</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest 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Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of occupational health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Shinobu</au><au>Hachiya, Yuriko</au><au>Yuasa, Eri</au><au>Takeuchi, Akito</au><au>Ishidao, Toru</au><au>Mihara, Mitsuhisa</au><au>Terauchi, Yasuhiro</au><au>Ichiba, Masayoshi</au><au>Hori, Hajime</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the ceiling levels of ortho‐phthalaldehyde exposure among health care workers engaged in endoscope disinfection: A new methodology using video‐exposure monitoring</atitle><jtitle>Journal of occupational health</jtitle><addtitle>J Occup Health</addtitle><date>2020-01</date><risdate>2020</risdate><volume>62</volume><issue>1</issue><spage>e12139</spage><epage>n/a</epage><pages>e12139-n/a</pages><issn>1348-9585</issn><issn>1341-9145</issn><eissn>1348-9585</eissn><abstract>Objectives
The present study aimed to develop a method for measuring the ceiling level of ortho‐phthalaldehyde (OPA) exposure and evaluate the ceiling levels of OPA exposure among health care workers who handle disinfectant solutions containing OPA for the disinfection of endoscopes.
Methods
The study consisted of a preliminary survey and main survey. In the preliminary survey, processes involving high‐concentration exposure to OPA were identified by video‐exposure monitoring (VEM). In the main survey, the ceiling levels of OPA exposure for high‐concentration exposure processes identified from the results of the preliminary survey were determined using a measuring method combining sampling using a 2,4‐dinitrophenylhydrazine‐silica cartridge and analysis by high‐performance liquid chromatography tandem mass spectrometry.
Results
In the preliminary survey, seven processes involving high‐concentration exposure to OPA were identified by VEM. The duration of each process was short, lasting from 20 seconds to a few minutes. In the main survey, the OPA concentrations for the identified high‐concentration exposure processes ranged from 1.18 to 4.49 ppb, which markedly exceeded the threshold limit value ceiling (TLV‐C) of 0.1 ppb recommended by the American Conference of Governmental Industrial Hygienists.
Conclusions
The method for measuring the ceiling level of OPA exposure was established using VEM and the highly sensitive method of chemical analysis; and we successfully evaluated the ceiling levels of OPA exposure among health care workers engaged in endoscope disinfection. This approach can also be applied to other chemical substances with recommended TLV‐Cs, and important information for reducing exposure can thus be obtained.</abstract><cop>Australia</cop><pub>John Wiley & Sons, Inc</pub><pmid>32713059</pmid><doi>10.1002/1348-9585.12139</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0523-1794</orcidid><orcidid>https://orcid.org/0000-0003-1782-6565</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of occupational health, 2020-01, Vol.62 (1), p.e12139-n/a |
| issn | 1348-9585 1341-9145 1348-9585 |
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| source | Oxford Journals Open Access Collection; J-STAGE Free; MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Camcorders Cameras Cartridges Chemical analysis Chromatography Disinfectants Disinfectants - adverse effects Disinfectants - analysis Disinfection Disinfection & disinfectants endoscope Endoscopes Environmental Monitoring - methods Equipment Contamination - prevention & control Exposure Gas flow Health care Health Personnel Humans Inhalation Exposure Liquid chromatography Mass spectrometry Mass spectroscopy measurement method Measurement methods Medical personnel Monitoring o-Phthalaldehyde - adverse effects o-Phthalaldehyde - analysis Occupational exposure Occupational Exposure - analysis Occupational health Original ortho‐phthalaldehyde Polls & surveys Scientific imaging Sensors Silica Silicon dioxide Surveys and Questionnaires threshold limit value‐ceiling video exposure monitoring VOCs Volatile organic compounds Workers |
| title | Evaluation of the ceiling levels of ortho‐phthalaldehyde exposure among health care workers engaged in endoscope disinfection: A new methodology using video‐exposure monitoring |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T16%3A31%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20ceiling%20levels%20of%20ortho%E2%80%90phthalaldehyde%20exposure%20among%20health%20care%20workers%20engaged%20in%20endoscope%20disinfection:%20A%20new%20methodology%20using%20video%E2%80%90exposure%20monitoring&rft.jtitle=Journal%20of%20occupational%20health&rft.au=Yamamoto,%20Shinobu&rft.date=2020-01&rft.volume=62&rft.issue=1&rft.spage=e12139&rft.epage=n/a&rft.pages=e12139-n/a&rft.issn=1348-9585&rft.eissn=1348-9585&rft_id=info:doi/10.1002/1348-9585.12139&rft_dat=%3Cproquest_pubme%3E2472960001%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2472960001&rft_id=info:pmid/32713059&rfr_iscdi=true |