3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase

3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase

BACKGROUND AND PURPOSE:A recombinant engineered variant of APC (activated protein C), 3K3A-APC, lacks anticoagulant properties (

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Bibliographische Detailangaben
Veröffentlicht in:Stroke (1970) 2020-07, Vol.51 (7), p.2236-2239
Hauptverfasser: Mukherjee, Purba, Lyden, Patrick, Fernández, José A., Davis, Thomas P., Pryor, Kent E., Zlokovic, Berislav V., Griffin, John H.
Format: Artikel
Sprache:eng
Schlagworte:
Fibrinolysis - drug effects
Fibrinolytic Agents - pharmacology
Humans
In Vitro Techniques
Protein C - pharmacology
Recombinant Proteins - pharmacology
Tenecteplase - pharmacology
Thrombosis
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Beschreibung
Zusammenfassung:BACKGROUND AND PURPOSE:A recombinant engineered variant of APC (activated protein C), 3K3A-APC, lacks anticoagulant properties (
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.120.028793