An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

Two inoculations with a new SARS-CoV-2 mRNA-based vaccine that encodes a protein in the coronavirus spike elicited high titers of virus-neutralizing antibody in healthy adult volunteers. Virus-specific T-cell responses were also elicited. Interim findings indicated that a dose of 100 μg per injectio...

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Veröffentlicht in:	The New England journal of medicine 2020-11, Vol.383 (20), p.1920-1931
Hauptverfasser:	Jackson, Lisa A, Anderson, Evan J, Rouphael, Nadine G, Roberts, Paul C, Makhene, Mamodikoe, Coler, Rhea N, McCullough, Michele P, Chappell, James D, Denison, Mark R, Stevens, Laura J, Pruijssers, Andrea J, McDermott, Adrian, Flach, Britta, Doria-Rose, Nicole A, Corbett, Kizzmekia S, Morabito, Kaitlyn M, O’Dell, Sijy, Schmidt, Stephen D, Swanson, Phillip A, Padilla, Marcelino, Mascola, John R, Neuzil, Kathleen M, Bennett, Hamilton, Sun, Wellington, Peters, Etza, Makowski, Mat, Albert, Jim, Cross, Kaitlyn, Buchanan, Wendy, Pikaart-Tautges, Rhonda, Ledgerwood, Julie E, Graham, Barney S, Beigel, John H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergies Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Antibody Formation Betacoronavirus Clinical trials Coronavirus Infections - prevention & control Coronaviruses COVID-19 COVID-19 Vaccines Drug dosages Enrollments Enzyme-linked immunosorbent assay Female Glycoproteins Health care Humans Immune response Immunization Immunization, Secondary Infections Infectious diseases Lipids Male Medical research mRNA mRNA vaccines Myalgia Nanoparticles Original Pandemics - prevention & control Pneumonia, Viral - prevention & control RNA, Messenger - immunology SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - immunology Spike protein Statistical analysis T-Lymphocytes - immunology Urticaria Vaccination Vaccines Viral Vaccines - adverse effects Viral Vaccines - therapeutic use Young Adult
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Beschreibung
Zusammenfassung:	Two inoculations with a new SARS-CoV-2 mRNA-based vaccine that encodes a protein in the coronavirus spike elicited high titers of virus-neutralizing antibody in healthy adult volunteers. Virus-specific T-cell responses were also elicited. Interim findings indicated that a dose of 100 μg per injection maximized immune response and minimized the reactogenicity of the vaccine.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2022483