Analysis of factors affecting the prognosis of patients with cervical intraepithelial neoplasia 2

According to the 2014 World Health Organization Classification of Tumors of Female Reproductive Organs, patients with cervical intraepithelial neoplasia 2 (CIN2) have an equivocal diagnosis, but pl6 is considered as the reference index for CIN2. Positive pl6 expression in CIN2 is associated with high-grade squamous intraepithelial lesions (HSIL), whereas pl6 negative lesions are low-grade squamous intraepithelial lesions. The purpose of the present study was to examine the clinical value of pl6 and human papillomavirus (HPV) E6/E7 mRNA in the prognostication of patients with CIN2. From January 2013 to January 2016,108 patients were diagnosed with CIN2 by biopsy and followed up at 6-month intervals at Peking University People's Hospital (Beijing, China). The expression of HPV E6/E7 mRNA was detected by in situ hybridization, while the expression of pl6 and Ki-67 proteins was detected by immunohistochemistry. Of the 108 CIN2 cases, 20 progressed to HSIL/CIN3, 36 cases demonstrated persistence with CIN2 after the follow-up and 52 cases achieved regression (