Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET
Purpose This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh +/− , D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes. Methods A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation bet...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2020-07, Vol.37 (7), p.1703-1710 |
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| creator | Li, Sai-jiao Cheng, Yan-xiang Ye-Shang Zhou, Dan-ni Zhang, Yin Yin, Tai-lang Yang, Jing |
| description | Purpose
This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.
Methods
A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group.
Results
Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively,
P
|
| doi_str_mv | 10.1007/s10815-020-01793-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7376992</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2425988009</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-ba0c6fd2985839b6537f26538720c5f9ca601c3cd3e897b49a068b65d445b5883</originalsourceid><addsrcrecordid>eNp9kUtPxSAQhYnR-P4DLkwTN27QAUqBjYm58ZXcxI26JZRSb01bKrQa_73o9b1ww5DMN2c4HIT2CBwRAHEcCUjCMVDAQIRiWK6gTcIFw4IxWE134BJDXsgNtBXjAwAoSdk62mA050QStonms0XwnY--M202-Pal82FYNLGLmYnR28aMrsqem3GRBTcEX012bJ5c5qfR-s4lqh5dyK7uzvHZzQ5aq00b3e5H3Ua352c3s0s8v764mp3Osc1FPuLSgC3qiirJJVNlwZmoaTqloGB5rawpgFhmK-akEmWuDBQyYVWe85JLybbRyVJ3mMrOVdb1YzCtHkLTmfCivWn0707fLPS9f9KCiUIpmgQOPwSCf5xcHHXXROva1vTOT1HTHArF03ephB78QR_8FPpkL1GUKykTlii6pGzwMQZXfz2GgH4LSy_D0iks_R6WfrOx_9PG18hnOglgSyCmVn_vwvfuf2RfAeOkoA8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2425988009</pqid></control><display><type>article</type><title>Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Li, Sai-jiao ; Cheng, Yan-xiang ; Ye-Shang ; Zhou, Dan-ni ; Zhang, Yin ; Yin, Tai-lang ; Yang, Jing</creator><creatorcontrib>Li, Sai-jiao ; Cheng, Yan-xiang ; Ye-Shang ; Zhou, Dan-ni ; Zhang, Yin ; Yin, Tai-lang ; Yang, Jing</creatorcontrib><description><![CDATA[Purpose
This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.
Methods
A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group.
Results
Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively,
P
< 0.05) undergoing IVF insemination, the inv(9) adversely increasing the early miscarriage rate, either undergoing IVF (21.4% vs. 3.0%,
P
< 0.05) or ICSI (50.0% vs. 2.0%,
P
< 0.05) insemination, female carriers (23.08% vs. 2.87%,
P
< 0.05) or male carriers (44.44% vs. 2.87%,
P
< 0.05). For D/G groups, ICSI insemination may increase the implantation rate (44.8% vs. 23.69%,
P
< 0.05) and clinical pregnancy rate (78.6% vs. 40.65%,
P
< 0.05). 1/9/16qh
+/−
had no apparent adverse effect on the patient’s clinical outcomes.
Conclusions
Our study suggests that chromosome karyotype analysis is necessary for IVF patients in clinical practice; we should afford individual genetic counseling suggestion according to the polymorphism types.]]></description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-020-01793-8</identifier><identifier>PMID: 32451813</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abortion, Spontaneous - genetics ; Adult ; Chromosomes, Human ; Embryo Transfer ; Female ; Fertilization in Vitro ; Gene polymorphism ; Genetic counseling ; Genetics ; Gynecology ; Human Genetics ; Humans ; Implantation ; Infertility ; Infertility - genetics ; Karyotypes ; Karyotyping ; Male ; Medicine ; Medicine & Public Health ; Miscarriage ; Oocyte Retrieval ; Polymorphism, Genetic ; Pregnancy ; Pregnancy Rate ; Reproductive Medicine ; Retrospective Studies ; Sperm Injections, Intracytoplasmic ; Treatment Outcome</subject><ispartof>Journal of assisted reproduction and genetics, 2020-07, Vol.37 (7), p.1703-1710</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ba0c6fd2985839b6537f26538720c5f9ca601c3cd3e897b49a068b65d445b5883</citedby><cites>FETCH-LOGICAL-c474t-ba0c6fd2985839b6537f26538720c5f9ca601c3cd3e897b49a068b65d445b5883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376992/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376992/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32451813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Sai-jiao</creatorcontrib><creatorcontrib>Cheng, Yan-xiang</creatorcontrib><creatorcontrib>Ye-Shang</creatorcontrib><creatorcontrib>Zhou, Dan-ni</creatorcontrib><creatorcontrib>Zhang, Yin</creatorcontrib><creatorcontrib>Yin, Tai-lang</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><title>Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description><![CDATA[Purpose
This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.
Methods
A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group.
Results
Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively,
P
< 0.05) undergoing IVF insemination, the inv(9) adversely increasing the early miscarriage rate, either undergoing IVF (21.4% vs. 3.0%,
P
< 0.05) or ICSI (50.0% vs. 2.0%,
P
< 0.05) insemination, female carriers (23.08% vs. 2.87%,
P
< 0.05) or male carriers (44.44% vs. 2.87%,
P
< 0.05). For D/G groups, ICSI insemination may increase the implantation rate (44.8% vs. 23.69%,
P
< 0.05) and clinical pregnancy rate (78.6% vs. 40.65%,
P
< 0.05). 1/9/16qh
+/−
had no apparent adverse effect on the patient’s clinical outcomes.
Conclusions
Our study suggests that chromosome karyotype analysis is necessary for IVF patients in clinical practice; we should afford individual genetic counseling suggestion according to the polymorphism types.]]></description><subject>Abortion, Spontaneous - genetics</subject><subject>Adult</subject><subject>Chromosomes, Human</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gene polymorphism</subject><subject>Genetic counseling</subject><subject>Genetics</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Implantation</subject><subject>Infertility</subject><subject>Infertility - genetics</subject><subject>Karyotypes</subject><subject>Karyotyping</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Miscarriage</subject><subject>Oocyte Retrieval</subject><subject>Polymorphism, Genetic</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Reproductive Medicine</subject><subject>Retrospective Studies</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Treatment Outcome</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtPxSAQhYnR-P4DLkwTN27QAUqBjYm58ZXcxI26JZRSb01bKrQa_73o9b1ww5DMN2c4HIT2CBwRAHEcCUjCMVDAQIRiWK6gTcIFw4IxWE134BJDXsgNtBXjAwAoSdk62mA050QStonms0XwnY--M202-Pal82FYNLGLmYnR28aMrsqem3GRBTcEX012bJ5c5qfR-s4lqh5dyK7uzvHZzQ5aq00b3e5H3Ua352c3s0s8v764mp3Osc1FPuLSgC3qiirJJVNlwZmoaTqloGB5rawpgFhmK-akEmWuDBQyYVWe85JLybbRyVJ3mMrOVdb1YzCtHkLTmfCivWn0707fLPS9f9KCiUIpmgQOPwSCf5xcHHXXROva1vTOT1HTHArF03ephB78QR_8FPpkL1GUKykTlii6pGzwMQZXfz2GgH4LSy_D0iks_R6WfrOx_9PG18hnOglgSyCmVn_vwvfuf2RfAeOkoA8</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Li, Sai-jiao</creator><creator>Cheng, Yan-xiang</creator><creator>Ye-Shang</creator><creator>Zhou, Dan-ni</creator><creator>Zhang, Yin</creator><creator>Yin, Tai-lang</creator><creator>Yang, Jing</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200701</creationdate><title>Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET</title><author>Li, Sai-jiao ; Cheng, Yan-xiang ; Ye-Shang ; Zhou, Dan-ni ; Zhang, Yin ; Yin, Tai-lang ; Yang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ba0c6fd2985839b6537f26538720c5f9ca601c3cd3e897b49a068b65d445b5883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abortion, Spontaneous - genetics</topic><topic>Adult</topic><topic>Chromosomes, Human</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gene polymorphism</topic><topic>Genetic counseling</topic><topic>Genetics</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Implantation</topic><topic>Infertility</topic><topic>Infertility - genetics</topic><topic>Karyotypes</topic><topic>Karyotyping</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Miscarriage</topic><topic>Oocyte Retrieval</topic><topic>Polymorphism, Genetic</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Reproductive Medicine</topic><topic>Retrospective Studies</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Sai-jiao</creatorcontrib><creatorcontrib>Cheng, Yan-xiang</creatorcontrib><creatorcontrib>Ye-Shang</creatorcontrib><creatorcontrib>Zhou, Dan-ni</creatorcontrib><creatorcontrib>Zhang, Yin</creatorcontrib><creatorcontrib>Yin, Tai-lang</creatorcontrib><creatorcontrib>Yang, Jing</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Sai-jiao</au><au>Cheng, Yan-xiang</au><au>Ye-Shang</au><au>Zhou, Dan-ni</au><au>Zhang, Yin</au><au>Yin, Tai-lang</au><au>Yang, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>37</volume><issue>7</issue><spage>1703</spage><epage>1710</epage><pages>1703-1710</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract><![CDATA[Purpose
This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.
Methods
A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh
+/−
, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group.
Results
Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively,
P
< 0.05) undergoing IVF insemination, the inv(9) adversely increasing the early miscarriage rate, either undergoing IVF (21.4% vs. 3.0%,
P
< 0.05) or ICSI (50.0% vs. 2.0%,
P
< 0.05) insemination, female carriers (23.08% vs. 2.87%,
P
< 0.05) or male carriers (44.44% vs. 2.87%,
P
< 0.05). For D/G groups, ICSI insemination may increase the implantation rate (44.8% vs. 23.69%,
P
< 0.05) and clinical pregnancy rate (78.6% vs. 40.65%,
P
< 0.05). 1/9/16qh
+/−
had no apparent adverse effect on the patient’s clinical outcomes.
Conclusions
Our study suggests that chromosome karyotype analysis is necessary for IVF patients in clinical practice; we should afford individual genetic counseling suggestion according to the polymorphism types.]]></abstract><cop>New York</cop><pub>Springer US</pub><pmid>32451813</pmid><doi>10.1007/s10815-020-01793-8</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-0468 |
| ispartof | Journal of assisted reproduction and genetics, 2020-07, Vol.37 (7), p.1703-1710 |
| issn | 1058-0468 1573-7330 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7376992 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Abortion, Spontaneous - genetics Adult Chromosomes, Human Embryo Transfer Female Fertilization in Vitro Gene polymorphism Genetic counseling Genetics Gynecology Human Genetics Humans Implantation Infertility Infertility - genetics Karyotypes Karyotyping Male Medicine Medicine & Public Health Miscarriage Oocyte Retrieval Polymorphism, Genetic Pregnancy Pregnancy Rate Reproductive Medicine Retrospective Studies Sperm Injections, Intracytoplasmic Treatment Outcome |
| title | Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET |
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