Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET

Purpose This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh +/− , D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes. Methods A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh +/− , D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group. Results Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively, P