Performance of ZDOCK and IRAD in CAPRI rounds 39‐45

We report docking performance on the six targets of Critical Assessment of PRedicted Interactions (CAPRI) rounds 39‐45 that involved heteromeric protein‐protein interactions and had the solved structures released since the rounds were held. Our general strategy involved protein‐protein docking using ZDOCK, reranking using IRAD, and structural refinement using Rosetta. In addition, we made extensive use of experimental data to guide our docking runs. All the experimental information at the amino‐acid level proved correct. However, for two targets, we also used protein‐complex structures as templates for modeling interfaces. These resulted in incorrect predictions, presumably due to the low sequence identity between the targets and templates. Albeit a small number of targets, the performance described here compared somewhat less favorably with our previous CAPRI reports, which may be due to the CAPRI targets being increasingly challenging.