Glucocorticoids, sodium transport mediators, and respiratory distress syndrome in preterm infants

Background Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial sodium and liquid absorption, and further, respirato...

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Veröffentlicht in:	Pediatric research 2021-04, Vol.89 (5), p.1253-1260
Hauptverfasser:	Süvari, Liina, Helve, Otto M., Kari, M. Anneli, Turpeinen, L. Ursula, Palojärvi, P. Anniina, Leskinen, Markus J., Andersson, Sture, Janér, A. Cecilia
Format:	Artikel
Sprache:	eng
Schlagworte:	Betamethasone - chemistry Biological Transport Clinical Clinical Research Article Cross-Sectional Studies Epithelial Sodium Channels - genetics Female Fetal Blood - metabolism Gene expression Gene Expression Profiling Glucocorticoids - metabolism Humans Infant Infant, Newborn Infant, Premature Kinases Male Medicine Medicine & Public Health Newborn babies Pediatric Surgery Pediatrics Premature babies Prospective Studies Respiratory distress syndrome Respiratory Distress Syndrome, Newborn - physiopathology Sodium Sodium - chemistry Sodium-Potassium-Exchanging ATPase - metabolism Umbilical cord
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Zusammenfassung:	Background Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial sodium and liquid absorption, and further, respiratory morbidity, associate with cord blood GC concentrations. Methods The study included 64 infants delivered
ISSN:	0031-3998 1530-0447
DOI:	10.1038/s41390-020-1061-9