Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test
Abstract Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma en...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2020-07, Vol.7 (7), p.ofaa189-ofaa189 |
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| container_end_page | ofaa189 |
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| container_issue | 7 |
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| container_title | Open Forum Infectious Diseases |
| container_volume | 7 |
| creator | Kalyatanda, Gautam Rand, Kenneth Lindner, Martin S Hong, David K Sait Albayram, Mehmet Gregory, Jason Kresak, Jesse Ibne, Karim M Ali Cope, Jennifer R Roy, Shantanu Gary, Joy M Reddy, Varalakshmi Ahmed, Asim A |
| description | Abstract
Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis. |
| doi_str_mv | 10.1093/ofid/ofaa189 |
| format | Article |
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Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofaa189</identifier><identifier>PMID: 32715017</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Brief Report ; Encephalitis ; Health aspects ; Metronidazole ; Pentamidine isethionate</subject><ispartof>Open Forum Infectious Diseases, 2020-07, Vol.7 (7), p.ofaa189-ofaa189</ispartof><rights>The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2020</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-be1e315f548cde0d706d64c82a26a4bd793774bd93d503cb98319f864d68f33</citedby><cites>FETCH-LOGICAL-c460t-be1e315f548cde0d706d64c82a26a4bd793774bd93d503cb98319f864d68f33</cites><orcidid>0000-0003-3334-614X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371414/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371414/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Kalyatanda, Gautam</creatorcontrib><creatorcontrib>Rand, Kenneth</creatorcontrib><creatorcontrib>Lindner, Martin S</creatorcontrib><creatorcontrib>Hong, David K</creatorcontrib><creatorcontrib>Sait Albayram, Mehmet</creatorcontrib><creatorcontrib>Gregory, Jason</creatorcontrib><creatorcontrib>Kresak, Jesse</creatorcontrib><creatorcontrib>Ibne, Karim M Ali</creatorcontrib><creatorcontrib>Cope, Jennifer R</creatorcontrib><creatorcontrib>Roy, Shantanu</creatorcontrib><creatorcontrib>Gary, Joy M</creatorcontrib><creatorcontrib>Reddy, Varalakshmi</creatorcontrib><creatorcontrib>Ahmed, Asim A</creatorcontrib><title>Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test</title><title>Open Forum Infectious Diseases</title><description>Abstract
Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.</description><subject>Brief Report</subject><subject>Encephalitis</subject><subject>Health aspects</subject><subject>Metronidazole</subject><subject>Pentamidine isethionate</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kU1r3DAQhk1paUKSW3-Abu0hTvVhW9KlkO8UQhqS3MVYGu-q2JJr2Uvz76tll9JegmBG0jzzMsxbFJ8YPWNUi6-x8y4HAKb0u-KQC65KpWv5_p_7QXGS0k9KKWO0plJ_LA4El6ymTB4WmycYvTslDzH4sIHkN0iuPKxCTD6R2JEL6GFY5rUHMkBwk-97mHLpOlgc19D7OT_aVwLksYc0QHkBCR15wN9zeYsBJ5h9DOQZfy0YrA8r8oJpPi4-dNAnPNnno-L55vrl8q68_3H7_fL8vrRVQ-eyRYaC1V1dKeuQOkkb11RWceANVK2TWkiZsxaupsK2WgmmO9VUrlGdEEfFt53quLQDOothnqA34-QHmF5NBG_-rwS_Nqu4MVJIVrEqC3zZC0wxz59mM_hkMa8gYFyS4RWXNWdc1Bk926Er6NH40MWsaPNxOHgbA3Y-_583WvGaMbXVPt012CmmNGH3dy5GzdZcszXX7M3N-OcdHpfxbfIPfh-m8w</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Kalyatanda, Gautam</creator><creator>Rand, Kenneth</creator><creator>Lindner, Martin S</creator><creator>Hong, David K</creator><creator>Sait Albayram, Mehmet</creator><creator>Gregory, Jason</creator><creator>Kresak, Jesse</creator><creator>Ibne, Karim M Ali</creator><creator>Cope, Jennifer R</creator><creator>Roy, Shantanu</creator><creator>Gary, Joy M</creator><creator>Reddy, Varalakshmi</creator><creator>Ahmed, Asim A</creator><general>Oxford University Press</general><scope>TOX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3334-614X</orcidid></search><sort><creationdate>20200701</creationdate><title>Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test</title><author>Kalyatanda, Gautam ; Rand, Kenneth ; Lindner, Martin S ; Hong, David K ; Sait Albayram, Mehmet ; Gregory, Jason ; Kresak, Jesse ; Ibne, Karim M Ali ; Cope, Jennifer R ; Roy, Shantanu ; Gary, Joy M ; Reddy, Varalakshmi ; Ahmed, Asim A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-be1e315f548cde0d706d64c82a26a4bd793774bd93d503cb98319f864d68f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Brief Report</topic><topic>Encephalitis</topic><topic>Health aspects</topic><topic>Metronidazole</topic><topic>Pentamidine isethionate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalyatanda, Gautam</creatorcontrib><creatorcontrib>Rand, Kenneth</creatorcontrib><creatorcontrib>Lindner, Martin S</creatorcontrib><creatorcontrib>Hong, David K</creatorcontrib><creatorcontrib>Sait Albayram, Mehmet</creatorcontrib><creatorcontrib>Gregory, Jason</creatorcontrib><creatorcontrib>Kresak, Jesse</creatorcontrib><creatorcontrib>Ibne, Karim M Ali</creatorcontrib><creatorcontrib>Cope, Jennifer R</creatorcontrib><creatorcontrib>Roy, Shantanu</creatorcontrib><creatorcontrib>Gary, Joy M</creatorcontrib><creatorcontrib>Reddy, Varalakshmi</creatorcontrib><creatorcontrib>Ahmed, Asim A</creatorcontrib><collection>Access via Oxford University Press (Open Access Collection)</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalyatanda, Gautam</au><au>Rand, Kenneth</au><au>Lindner, Martin S</au><au>Hong, David K</au><au>Sait Albayram, Mehmet</au><au>Gregory, Jason</au><au>Kresak, Jesse</au><au>Ibne, Karim M Ali</au><au>Cope, Jennifer R</au><au>Roy, Shantanu</au><au>Gary, Joy M</au><au>Reddy, Varalakshmi</au><au>Ahmed, Asim A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test</atitle><jtitle>Open Forum Infectious Diseases</jtitle><date>2020-07-01</date><risdate>2020</risdate><volume>7</volume><issue>7</issue><spage>ofaa189</spage><epage>ofaa189</epage><pages>ofaa189-ofaa189</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32715017</pmid><doi>10.1093/ofid/ofaa189</doi><orcidid>https://orcid.org/0000-0003-3334-614X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Brief Report Encephalitis Health aspects Metronidazole Pentamidine isethionate |
| title | Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test |
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