Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test

Rapid, Noninvasive Diagnosis of Balamuthia mandrillaris Encephalitis by a Plasma-Based Next-Generation Sequencing Test

Abstract Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma en...

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Veröffentlicht in:Open Forum Infectious Diseases 2020-07, Vol.7 (7), p.ofaa189-ofaa189
Hauptverfasser: Kalyatanda, Gautam, Rand, Kenneth, Lindner, Martin S, Hong, David K, Sait Albayram, Mehmet, Gregory, Jason, Kresak, Jesse, Ibne, Karim M Ali, Cope, Jennifer R, Roy, Shantanu, Gary, Joy M, Reddy, Varalakshmi, Ahmed, Asim A
Format: Artikel
Sprache:eng
Schlagworte:
Brief Report
Encephalitis
Health aspects
Metronidazole
Pentamidine isethionate
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Zusammenfassung:Abstract Granulomatous amoebic encephalitis (GAE) caused by Balamuthia mandrillaris is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of Balamuthia mandrillaris cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofaa189