Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI
Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may al...
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Veröffentlicht in: | Experimental neurology 2019-08, Vol.318, p.78-91 |
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container_title | Experimental neurology |
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creator | Sta Maria, Naomi S. Sargolzaei, Saman Prins, Mayumi L. Dennis, Emily L. Asarnow, Robert F. Hovda, David A. Harris, Neil G. Giza, Christopher C. |
description | Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up. |
doi_str_mv | 10.1016/j.expneurol.2019.04.016 |
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The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2019.04.016</identifier><identifier>PMID: 31055004</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Brain Injuries, Traumatic - physiopathology ; Child ; Child, Preschool ; Development ; Humans ; Infant ; Infant, Newborn ; Nerve Regeneration - physiology ; Neuronal Plasticity - physiology ; Pediatric TBI ; Plasticity ; Recovery of Function - physiology ; Traumatic brain injury</subject><ispartof>Experimental neurology, 2019-08, Vol.318, p.78-91</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. 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Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.</description><subject>Brain Injuries, Traumatic - physiopathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Development</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Nerve Regeneration - physiology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Pediatric TBI</subject><subject>Plasticity</subject><subject>Recovery of Function - physiology</subject><subject>Traumatic brain injury</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAUtBAVXQp_AXzkkvT5K044ILUV0JWKuJSz5bVfdr3KJsH2Vu2_r6stK3rq6Unz5s08zRDymUHNgDXn2xrv5xH3cRpqDqyrQdYFf0MWDDqouBTwliwAmKxk2zan5H1KWwDoJNfvyKlgoBSAXJDlZQx-HcY1zRukazt_pb_QbewY0i7RqafzYFMOLuQHakdPI842RGr7jJHO6IPNMTh6e7n8QE56OyT8-DzPyJ8f32-vrqub3z-XVxc3lZNa5aqDfsWhbaRqJetb9EJyq2SjceVXKDlTHTjhWyGVtuVfbfvWd6znHePK6VackW8H3Xm_2qF3OOZoBzPHsLPxwUw2mJebMWzMerozWmgmmqYIfHkWiNPfPaZsdiE5HAY74rRPhnPBOqWYYoWqD1QXp5Qi9kcbBuapCLM1xyLMUxEGpCl4ufz0_5fHu3_JF8LFgYAlq7uA0SQXcHQl0oguGz-FV00eAQ-6nkw</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Sta Maria, Naomi S.</creator><creator>Sargolzaei, Saman</creator><creator>Prins, Mayumi L.</creator><creator>Dennis, Emily L.</creator><creator>Asarnow, Robert F.</creator><creator>Hovda, David A.</creator><creator>Harris, Neil G.</creator><creator>Giza, Christopher C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1965-6750</orcidid></search><sort><creationdate>20190801</creationdate><title>Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI</title><author>Sta Maria, Naomi S. ; Sargolzaei, Saman ; Prins, Mayumi L. ; Dennis, Emily L. ; Asarnow, Robert F. ; Hovda, David A. ; Harris, Neil G. ; Giza, Christopher C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-90fb208645841f8ed342a5467ebdbe421590c3d83457a0947af8d91f29125c783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Brain Injuries, Traumatic - physiopathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Development</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Nerve Regeneration - physiology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Pediatric TBI</topic><topic>Plasticity</topic><topic>Recovery of Function - physiology</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sta Maria, Naomi S.</creatorcontrib><creatorcontrib>Sargolzaei, Saman</creatorcontrib><creatorcontrib>Prins, Mayumi L.</creatorcontrib><creatorcontrib>Dennis, Emily L.</creatorcontrib><creatorcontrib>Asarnow, Robert F.</creatorcontrib><creatorcontrib>Hovda, David A.</creatorcontrib><creatorcontrib>Harris, Neil G.</creatorcontrib><creatorcontrib>Giza, Christopher C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sta Maria, Naomi S.</au><au>Sargolzaei, Saman</au><au>Prins, Mayumi L.</au><au>Dennis, Emily L.</au><au>Asarnow, Robert F.</au><au>Hovda, David A.</au><au>Harris, Neil G.</au><au>Giza, Christopher C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>318</volume><spage>78</spage><epage>91</epage><pages>78-91</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><abstract>Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. 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subjects | Brain Injuries, Traumatic - physiopathology Child Child, Preschool Development Humans Infant Infant, Newborn Nerve Regeneration - physiology Neuronal Plasticity - physiology Pediatric TBI Plasticity Recovery of Function - physiology Traumatic brain injury |
title | Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI |
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