Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI

Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may al...

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Veröffentlicht in:Experimental neurology 2019-08, Vol.318, p.78-91
Hauptverfasser: Sta Maria, Naomi S., Sargolzaei, Saman, Prins, Mayumi L., Dennis, Emily L., Asarnow, Robert F., Hovda, David A., Harris, Neil G., Giza, Christopher C.
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container_issue
container_start_page 78
container_title Experimental neurology
container_volume 318
creator Sta Maria, Naomi S.
Sargolzaei, Saman
Prins, Mayumi L.
Dennis, Emily L.
Asarnow, Robert F.
Hovda, David A.
Harris, Neil G.
Giza, Christopher C.
description Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.
doi_str_mv 10.1016/j.expneurol.2019.04.016
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subjects Brain Injuries, Traumatic - physiopathology
Child
Child, Preschool
Development
Humans
Infant
Infant, Newborn
Nerve Regeneration - physiology
Neuronal Plasticity - physiology
Pediatric TBI
Plasticity
Recovery of Function - physiology
Traumatic brain injury
title Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI
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