Downregulation of LUZP2 Is Correlated with Poor Prognosis of Low-Grade Glioma

Background. LUZP2 is a protein limitedly expressed in the brain and spinal cord, while there are few studies on it in brain tumors. Low-grade glioma (LGG) is one of the most common brain tumors. However, the biological behavior of LGG is not very clear at present. This study was aimed at exploring t...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-16
Hauptverfasser:	Chen, Qianxue, Liu, Baohui, Geng, Rongxin, Jiang, Hongxiang, Zhang, Huikai, Qi, Yangzhi, Deng, Gang, Li, Yong, Ye, Zhang
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Biomarkers Brain Brain cancer Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Data bases Data mining Datasets DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation - genetics Extracellular matrix Gender Gene expression Gene Expression Regulation, Neoplastic Gene Ontology Gene Regulatory Networks Genes Genomes Glioma Glioma - genetics Glioma - pathology Gliomas Histology Humans Intellectual disabilities Kaplan-Meier Estimate Medical prognosis Metabolic pathways MicroRNAs - genetics MicroRNAs - metabolism Multivariate analysis Neoplasm Grading Nervous system Patients Prognosis Proportional Hazards Models Prostate cancer Radiation therapy Regulatory mechanisms (biology) RNA, Messenger - genetics RNA, Messenger - metabolism Spinal cord Survival Analysis Transcription factors Transcription Factors - metabolism Tumors Up-Regulation - genetics
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Zusammenfassung:	Background. LUZP2 is a protein limitedly expressed in the brain and spinal cord, while there are few studies on it in brain tumors. Low-grade glioma (LGG) is one of the most common brain tumors. However, the biological behavior of LGG is not very clear at present. This study was aimed at exploring the role of LUZP2 in LGG. Methods. By data mining in The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA), the expression, clinical characteristics, and potential regulatory mechanism of LUZP2 in LGG were assessed. The regulatory miRNAs of LUZP2 were predicted using miRDB, TargetScan, and miRTarBase. Meanwhile, the potential biological function of coexpressed genes was investigated by GO and KEGG analyses. Results. LUZP2 expression was downregulated with the increase of tumor grade (p
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2020/9716720