Cytokine-associated fatigue prior to, during, and post-chemotherapy for breast cancer

Cytokine-associated fatigue prior to, during, and post-chemotherapy for breast cancer

[Display omitted] •Cytokine concentrations were associated with fatigue across treatment phases; greatest impact during chemotherapy period.•Cognition was related to pre-chemotherapy fatigue and at follow-up; not during chemotherapy.•Pro-inflammatory cytokines peaked during chemotherapy, then decrea...

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Veröffentlicht in:Journal of neuroimmunology 2019-09, Vol.334, p.577001-577001, Article 577001
Hauptverfasser: Cohen, R.A., Gullett, J.M., Woods, A.J., Porges, E.C., Starkweather, A., Jackson-Cook, C.K., Lynch-Kelly, D.L., Lyon, D.E.
Format: Artikel
Sprache:eng
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Zusammenfassung:[Display omitted] •Cytokine concentrations were associated with fatigue across treatment phases; greatest impact during chemotherapy period.•Cognition was related to pre-chemotherapy fatigue and at follow-up; not during chemotherapy.•Pro-inflammatory cytokines peaked during chemotherapy, then decreased to pre-chemotherapy levels at 24-month follow-up•Relationships between specific cytokines and fatigue varied across treatment phases•Cytokines linked to fatigue beyond clinical factors; but neoadjuvent therapy and progesterone positivity had some impact
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2019.577001