Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates
Background To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance ( R ) and lower reactance ( X ) on day 1. Methods Healthy term infants ( n = 138...
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| Veröffentlicht in: | Pediatric research 2020-08, Vol.88 (2), p.293-299 |
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| container_title | Pediatric research |
| container_volume | 88 |
| creator | Klinger, Andrew P. Travers, Colm P. Martin, Abigail Kuo, Hui-Chien Alishlash, Ammar Saadoon Harris, William T. Carlo, Waldemar A. Ambalavanan, Namasivayam |
| description | Background
To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance (
R
) and lower reactance (
X
) on day 1.
Methods
Healthy term infants (
n
= 138) and infants with TTN (
n
= 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™.
R
,
X
, and area under the reactance curve (AX) were measured at prime frequencies 7–41 Hz for 8 s.
Results
In all, 86% of control infants had adequate measurements (coherence >0.8, CV |
| doi_str_mv | 10.1038/s41390-020-0751-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7358118</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2338988537</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-38292e4c577be2ca3ee1dd5c355461b48bf2e39893634f81a58cb214432643853</originalsourceid><addsrcrecordid>eNp9kU9rHSEUxaW0NK9pP0A3ZaCbbqZRr466KZSQNoGQLpKuxfHdSQwz-qIzD963r4-Xpn-gXYjo_XmOh0PIW0Y_Mgr6pAgGhraU16Uka9UzsmIS6kkI9ZysKAXWgjH6iLwq5Z5SJqQWL8kRMANSiW5Frq9SbEPcuhK22Awpe1w3qfgwjmnCOe-aOTUPi4tzGHZNxrIJ2c2p3k_o71wMvjQhNjPmqYmYopuxvCYvBjcWfPO4H5PvX85uTs_by29fL04_X7ZeGD23oLnhKLxUqkfuHSCy9Vp6kFJ0rBe6HziC0QY6EINmTmrfcyYE8E6AlnBMPh10N0s_4dpjnLMb7SaHyeWdTS7YPycx3NnbtLUKpGZMV4EPjwI5PSxYZjuF4nEcXY2yFMsBtNHVSVX0_V_ofVpyrPEsF6pTHSgF_6e4AgPA9hQ7UD6nUjIOT19m1O6LtYdibS3W7ou1e_93v2d9evGzyQrwA1DqKN5i_mX9b9Uf-SGt_Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2427393313</pqid></control><display><type>article</type><title>Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Klinger, Andrew P. ; Travers, Colm P. ; Martin, Abigail ; Kuo, Hui-Chien ; Alishlash, Ammar Saadoon ; Harris, William T. ; Carlo, Waldemar A. ; Ambalavanan, Namasivayam</creator><creatorcontrib>Klinger, Andrew P. ; Travers, Colm P. ; Martin, Abigail ; Kuo, Hui-Chien ; Alishlash, Ammar Saadoon ; Harris, William T. ; Carlo, Waldemar A. ; Ambalavanan, Namasivayam</creatorcontrib><description>Background
To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance (
R
) and lower reactance (
X
) on day 1.
Methods
Healthy term infants (
n
= 138) and infants with TTN (
n
= 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™.
R
,
X
, and area under the reactance curve (AX) were measured at prime frequencies 7–41 Hz for 8 s.
Results
In all, 86% of control infants had adequate measurements (coherence >0.8, CV < 0.25) on day 1. Infants with TTN had higher resistance at 13 Hz (TTN 32.5 cm H
2
O·s/L [95% CI 25.5–39.4]; controls 23.8 cm H
2
O·s/L [95% CI 22.2 to 25.3],
P
= 0.007) and lower reactance from 17 to 37 Hz (TTN −35.1 to −10.5; controls −26.3 to −6.1,
P
< 0.05). In healthy controls, lung mechanics were unchanged from days 1 to 3. In TTN, lung mechanics normalized on days 2 and 3.
Conclusions
FOT is feasible in neonates and distinguishes normal control infants from those with TTN on postnatal day 1. Oscillometry offers a non-invasive, longitudinal technique to assess lung mechanics in newborns.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-020-0751-7</identifier><identifier>PMID: 31935746</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Airway Resistance ; Asthma ; Clinical Research Article ; Female ; Forced Expiratory Volume ; Humans ; Infant, Newborn ; Lung - physiopathology ; Male ; Mechanics ; Medicine ; Medicine & Public Health ; Oscillometry - methods ; Pediatric Surgery ; Pediatrics ; Prospective Studies ; Respiratory Function Tests - methods ; Respiratory Mechanics ; Spirometry ; Tachypnea - physiopathology ; Vital Capacity</subject><ispartof>Pediatric research, 2020-08, Vol.88 (2), p.293-299</ispartof><rights>International Pediatric Research Foundation, Inc 2020</rights><rights>International Pediatric Research Foundation, Inc 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-38292e4c577be2ca3ee1dd5c355461b48bf2e39893634f81a58cb214432643853</citedby><cites>FETCH-LOGICAL-c498t-38292e4c577be2ca3ee1dd5c355461b48bf2e39893634f81a58cb214432643853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31935746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klinger, Andrew P.</creatorcontrib><creatorcontrib>Travers, Colm P.</creatorcontrib><creatorcontrib>Martin, Abigail</creatorcontrib><creatorcontrib>Kuo, Hui-Chien</creatorcontrib><creatorcontrib>Alishlash, Ammar Saadoon</creatorcontrib><creatorcontrib>Harris, William T.</creatorcontrib><creatorcontrib>Carlo, Waldemar A.</creatorcontrib><creatorcontrib>Ambalavanan, Namasivayam</creatorcontrib><title>Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance (
R
) and lower reactance (
X
) on day 1.
Methods
Healthy term infants (
n
= 138) and infants with TTN (
n
= 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™.
R
,
X
, and area under the reactance curve (AX) were measured at prime frequencies 7–41 Hz for 8 s.
Results
In all, 86% of control infants had adequate measurements (coherence >0.8, CV < 0.25) on day 1. Infants with TTN had higher resistance at 13 Hz (TTN 32.5 cm H
2
O·s/L [95% CI 25.5–39.4]; controls 23.8 cm H
2
O·s/L [95% CI 22.2 to 25.3],
P
= 0.007) and lower reactance from 17 to 37 Hz (TTN −35.1 to −10.5; controls −26.3 to −6.1,
P
< 0.05). In healthy controls, lung mechanics were unchanged from days 1 to 3. In TTN, lung mechanics normalized on days 2 and 3.
Conclusions
FOT is feasible in neonates and distinguishes normal control infants from those with TTN on postnatal day 1. Oscillometry offers a non-invasive, longitudinal technique to assess lung mechanics in newborns.</description><subject>Airway Resistance</subject><subject>Asthma</subject><subject>Clinical Research Article</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Mechanics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oscillometry - methods</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Respiratory Function Tests - methods</subject><subject>Respiratory Mechanics</subject><subject>Spirometry</subject><subject>Tachypnea - physiopathology</subject><subject>Vital Capacity</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU9rHSEUxaW0NK9pP0A3ZaCbbqZRr466KZSQNoGQLpKuxfHdSQwz-qIzD963r4-Xpn-gXYjo_XmOh0PIW0Y_Mgr6pAgGhraU16Uka9UzsmIS6kkI9ZysKAXWgjH6iLwq5Z5SJqQWL8kRMANSiW5Frq9SbEPcuhK22Awpe1w3qfgwjmnCOe-aOTUPi4tzGHZNxrIJ2c2p3k_o71wMvjQhNjPmqYmYopuxvCYvBjcWfPO4H5PvX85uTs_by29fL04_X7ZeGD23oLnhKLxUqkfuHSCy9Vp6kFJ0rBe6HziC0QY6EINmTmrfcyYE8E6AlnBMPh10N0s_4dpjnLMb7SaHyeWdTS7YPycx3NnbtLUKpGZMV4EPjwI5PSxYZjuF4nEcXY2yFMsBtNHVSVX0_V_ofVpyrPEsF6pTHSgF_6e4AgPA9hQ7UD6nUjIOT19m1O6LtYdibS3W7ou1e_93v2d9evGzyQrwA1DqKN5i_mX9b9Uf-SGt_Q</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Klinger, Andrew P.</creator><creator>Travers, Colm P.</creator><creator>Martin, Abigail</creator><creator>Kuo, Hui-Chien</creator><creator>Alishlash, Ammar Saadoon</creator><creator>Harris, William T.</creator><creator>Carlo, Waldemar A.</creator><creator>Ambalavanan, Namasivayam</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200801</creationdate><title>Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates</title><author>Klinger, Andrew P. ; Travers, Colm P. ; Martin, Abigail ; Kuo, Hui-Chien ; Alishlash, Ammar Saadoon ; Harris, William T. ; Carlo, Waldemar A. ; Ambalavanan, Namasivayam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-38292e4c577be2ca3ee1dd5c355461b48bf2e39893634f81a58cb214432643853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Airway Resistance</topic><topic>Asthma</topic><topic>Clinical Research Article</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Mechanics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oscillometry - methods</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Prospective Studies</topic><topic>Respiratory Function Tests - methods</topic><topic>Respiratory Mechanics</topic><topic>Spirometry</topic><topic>Tachypnea - physiopathology</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klinger, Andrew P.</creatorcontrib><creatorcontrib>Travers, Colm P.</creatorcontrib><creatorcontrib>Martin, Abigail</creatorcontrib><creatorcontrib>Kuo, Hui-Chien</creatorcontrib><creatorcontrib>Alishlash, Ammar Saadoon</creatorcontrib><creatorcontrib>Harris, William T.</creatorcontrib><creatorcontrib>Carlo, Waldemar A.</creatorcontrib><creatorcontrib>Ambalavanan, Namasivayam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klinger, Andrew P.</au><au>Travers, Colm P.</au><au>Martin, Abigail</au><au>Kuo, Hui-Chien</au><au>Alishlash, Ammar Saadoon</au><au>Harris, William T.</au><au>Carlo, Waldemar A.</au><au>Ambalavanan, Namasivayam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>88</volume><issue>2</issue><spage>293</spage><epage>299</epage><pages>293-299</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance (
R
) and lower reactance (
X
) on day 1.
Methods
Healthy term infants (
n
= 138) and infants with TTN (
n
= 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™.
R
,
X
, and area under the reactance curve (AX) were measured at prime frequencies 7–41 Hz for 8 s.
Results
In all, 86% of control infants had adequate measurements (coherence >0.8, CV < 0.25) on day 1. Infants with TTN had higher resistance at 13 Hz (TTN 32.5 cm H
2
O·s/L [95% CI 25.5–39.4]; controls 23.8 cm H
2
O·s/L [95% CI 22.2 to 25.3],
P
= 0.007) and lower reactance from 17 to 37 Hz (TTN −35.1 to −10.5; controls −26.3 to −6.1,
P
< 0.05). In healthy controls, lung mechanics were unchanged from days 1 to 3. In TTN, lung mechanics normalized on days 2 and 3.
Conclusions
FOT is feasible in neonates and distinguishes normal control infants from those with TTN on postnatal day 1. Oscillometry offers a non-invasive, longitudinal technique to assess lung mechanics in newborns.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31935746</pmid><doi>10.1038/s41390-020-0751-7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric research, 2020-08, Vol.88 (2), p.293-299 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7358118 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Airway Resistance Asthma Clinical Research Article Female Forced Expiratory Volume Humans Infant, Newborn Lung - physiopathology Male Mechanics Medicine Medicine & Public Health Oscillometry - methods Pediatric Surgery Pediatrics Prospective Studies Respiratory Function Tests - methods Respiratory Mechanics Spirometry Tachypnea - physiopathology Vital Capacity |
| title | Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates |
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