Non-invasive forced oscillometry to quantify respiratory mechanics in term neonates

Background To determine normative data by forced oscillation technique (FOT) in non-sedated normal term neonates and test the hypothesis that infants with transient tachypnea of the newborn (TTN) have higher resistance ( R ) and lower reactance ( X ) on day 1. Methods Healthy term infants ( n = 138) and infants with TTN ( n = 17) were evaluated on postnatal days 1 through 3 (NCT03346343). FOT was measured with a mask using a TremoFlo C-100 Airwave System™. R , X , and area under the reactance curve (AX) were measured at prime frequencies 7–41 Hz for 8 s. Results In all, 86% of control infants had adequate measurements (coherence >0.8, CV