Freedom of assembly: metabolic enzymes come together

Many different enzymes in intermediate metabolism dynamically assemble filamentous polymers in cells, often in response to changes in physiological conditions. Most of the enzyme filaments known to date have only been observed in cells, but in a handful of cases structural and biochemical studies ha...

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Veröffentlicht in:Molecular biology of the cell 2020-06, Vol.31 (12), p.1201-1205
Hauptverfasser: Simonet, Jacqueline C, Burrell, Anika L, Kollman, Justin M, Peterson, Jeffrey R
Format: Artikel
Sprache:eng
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Zusammenfassung:Many different enzymes in intermediate metabolism dynamically assemble filamentous polymers in cells, often in response to changes in physiological conditions. Most of the enzyme filaments known to date have only been observed in cells, but in a handful of cases structural and biochemical studies have revealed the mechanisms and consequences of assembly. In general, enzyme polymerization functions as a mechanism to allosterically tune enzyme kinetics, and it may play a physiological role in integrating metabolic signaling. Here, we highlight some principles of metabolic filaments by focusing on two well-studied examples in nucleotide biosynthesis pathways-inosine-5'-monophosphate (IMP) dehydrogenase and cytosine triphosphate (CTP) synthase.
ISSN:1059-1524
1939-4586
DOI:10.1091/mbc.e18-10-0675