Editorial for the Special Issue "Animal Models of Parkinson's Disease and Related Disorders"

[9] developed a new rotenone mouse model which exhibited motor deficits and α-synuclein-positive neuronal inclusions in the substantia nigra pars compacta, the dorsal motor nucleus of the vagus, and the intestinal myenteric plexus, reproducing a neuropathological feature of PD. Hyposmia, constipation, and rapid eye movement sleep behavior disorder are considered prodromal symptoms of PD that often precede motor symptoms. [17] reviewed the roles of a hypoxia-inducible factor (HIF)-1 negative regulator, Inhibitory PAS domain protein (IPAS), in the PINK1 and Parkin pathway using cultured cells and mice. [18] reported the suppression of general protein synthesis by eIF2α phosphorylation though protein kinase RNA-like endoplasmic reticulum kinase (PERK) activation is protective against dopaminergic neuron loss in Drosophila. Abbreviations 6-OHDA 6-Hydroxydopamine DLB Dementia with Lewy bodies HIF-1 hypoxia-inducible factor-1 IPAS Inhibitory PAS domain protein LB Lewy body MPP+ 1-Methyl-4-phenylpyridinium MPTP 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine PD Parkinson's disease PERK Protein kinase RNA-like endoplasmic reticulum kinase ROS Reactive oxygen species 1.