The Expressions and Mechanisms of Sarcomeric Proteins in Cancers

The sarcomeric proteins control the movement of cells in diverse species, whereas the deregulation can induce tumours in model organisms and occurs in human carcinomas. Sarcomeric proteins are recognized as oncogene and related to tumor cell metastasis. Recent insights into their expressions and fun...

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Veröffentlicht in:	Disease markers 2020, Vol.2020 (2020), p.1-16
Hauptverfasser:	Hu, Chaosu, Guo, Xiaomao, Ren, Hanru, Yang, Xiaojing, Fu, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Analysis Bladder cancer Breast cancer Cancer Carcinoma Cell adhesion & migration Cell cycle Cell growth Cytoskeleton Deregulation Genes Kinases Leukemia Localization Metastases Metastasis Muscle proteins Muscles Musculoskeletal system Myosin Physiology Prostate cancer Protein binding Proteins Review Sarcoma Signal transduction Smooth muscle Stem cells Tumorigenesis Tumors
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Beschreibung
Zusammenfassung:	The sarcomeric proteins control the movement of cells in diverse species, whereas the deregulation can induce tumours in model organisms and occurs in human carcinomas. Sarcomeric proteins are recognized as oncogene and related to tumor cell metastasis. Recent insights into their expressions and functions have led to new cancer therapeutic opportunities. In this review, we appraise the evidence for the sarcomeric proteins as cancer genes and discuss cancer-relevant biological functions, potential mechanisms by which sarcomeric proteins activity is altered in cancer.
ISSN:	0278-0240 1875-8630
DOI:	10.1155/2020/8885286