Exosome-transmitted long non-coding RNA SENP3-EIF4A1 suppresses the progression of hepatocellular carcinoma

Extracellular communication mediated by exosomes in a tumor microenvironment can substantially affect tumor progression. However, the effect of exosomal long non-coding RNA SENP3 EIF4A1 on hepatocellular carcinoma (HCC) is still unclear. In this study, SENP3 EIF4A1 expressions in patients with HCC a...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-06, Vol.12 (12), p.11550-11567
Hauptverfasser:	Wang, Jianchu, Pu, Jian, Zhang, Ying, Yao, Tianwei, Luo, Zongjiang, Li, Wenchuan, Xu, Guidan, Liu, Juan, Wei, Wujun, Deng, Yibin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Case-Control Studies Cell Biology Cell Line, Tumor Cell Proliferation Disease Progression Exosomes - metabolism Female Gene Expression Regulation, Neoplastic Geriatrics & Gerontology Healthy Volunteers Humans Life Sciences & Biomedicine Liver - pathology Liver Neoplasms - blood Liver Neoplasms - genetics Liver Neoplasms - pathology Male Mice MicroRNAs - metabolism Middle Aged Research Paper RNA, Long Noncoding - blood RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Science & Technology Tristetraprolin - genetics Xenograft Model Antitumor Assays
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Zusammenfassung:	Extracellular communication mediated by exosomes in a tumor microenvironment can substantially affect tumor progression. However, the effect of exosomal long non-coding RNA SENP3 EIF4A1 on hepatocellular carcinoma (HCC) is still unclear. In this study, SENP3 EIF4A1 expressions in patients with HCC and healthy controls were detected and compared. Results showed that SENP3-EIF4A1 was significantly reduced in HCC tissues and exosomes from the plasma of patients with HCC (P
ISSN:	1945-4589 1945-4589
DOI:	10.18632/aging.103302